{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:39:31Z","timestamp":1793493571943,"version":"4.5.0"},"reference-count":37,"publisher":"American Society for Clinical Investigation","issue":"14","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102253"],"award-info":[{"award-number":["82102253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Shanghai","award":["21ZR1413400"],"award-info":[{"award-number":["21ZR1413400"]}]},{"name":"Shanghai Sailing Program","award":["21YF1406800"],"award-info":[{"award-number":["21YF1406800"]}]},{"name":"the Shanghai Municipal 2021 \u201cScience and Technology Innovation Action Plan\u201d","award":["21JC1401400"],"award-info":[{"award-number":["21JC1401400"]}]},{"name":"Natural Science Foundation of Shanghai Municipal Commission of Science and Technology","award":["23ZR1411400"],"award-info":[{"award-number":["23ZR1411400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,22]]},"abstract":"<jats:p>\n                    The excessive formation and release of neutrophil extracellular traps (NETs) in sepsis may represent a substantial mechanism contributing to multiorgan damage, which is associated with a poor prognosis. However, the precise role of NETs in mediating the transition from innate immunity to adaptive immunity during the progression of inflammation and sepsis remains incompletely elucidated. In this study, we provide evidence that, despite a reduction in the number of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the late stage of sepsis, there is a notable upregulation in the proportion of Tregs. Mechanistically, we have identified that NETs can induce metabolic reprogramming of naive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells through the Akt\/mTOR\/SREBP2 pathway, resulting in enhanced cholesterol metabolism, thereby promoting their conversion into Tregs and augmenting their functional capacity. Collectively, our findings highlight the potential therapeutic strategy of targeting intracellular cholesterol normalization for the management of immunosuppressed patients with sepsis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.180132","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:00:58Z","timestamp":1718712058000},"source":"Crossref","is-referenced-by-count":55,"title":["Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis"],"prefix":"10.1172","volume":"9","author":[{"given":"Yuxin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China."},{"name":"Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China."},{"name":"Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, 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