{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:52:09Z","timestamp":1791021129176,"version":"4.1.0"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"14","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01AI66358"],"award-info":[{"award-number":["R01AI66358"]}]},{"name":"National Institute of Health","award":["R01AI134879"],"award-info":[{"award-number":["R01AI134879"]}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01CX001460"],"award-info":[{"award-number":["I01CX001460"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01BX005422"],"award-info":[{"award-number":["I01BX005422"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,22]]},"abstract":"<jats:p>\n                    Memory T cells are conventionally associated with durable recall responses. In our longitudinal analyses of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses to the yellow fever virus (YFV) vaccine by peptide-MHC tetramers, we unexpectedly found CD45RO\n                    <jats:sup>\u2013<\/jats:sup>\n                    CCR7\n                    <jats:sup>+<\/jats:sup>\n                    virus-specific CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that expanded shortly after vaccination and persisted months to years after immunization. Further phenotypic analyses revealed the presence of stem cell\u2013like memory T cells within this subset. In addition, after vaccination T cells lacking known memory markers and functionally resembling genuine naive T cells were identified, referred to herein as marker-negative T (T\n                    <jats:sub>MN<\/jats:sub>\n                    ) cells. Single-cell TCR sequencing detected expanded clonotypes within the T\n                    <jats:sub>MN<\/jats:sub>\n                    subset and identified T\n                    <jats:sub>MN<\/jats:sub>\n                    TCRs shared with memory and effector T cells. Longitudinal tracking of YFV-specific responses over subsequent years revealed superior stability of T\n                    <jats:sub>MN<\/jats:sub>\n                    cells, which correlated with the longevity of the overall tetramer\n                    <jats:sup>+<\/jats:sup>\n                    population. These findings uncover additional complexity within the post-immune T cell compartment and implicate T\n                    <jats:sub>MN<\/jats:sub>\n                    cells in durable immune responses.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.180667","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T13:14:02Z","timestamp":1718111642000},"source":"Crossref","is-referenced-by-count":7,"title":["Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity"],"prefix":"10.1172","volume":"9","author":[{"given":"Yi-Gen","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bartolo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruozhang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."},{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."},{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika I.","family":"Zarnitsyna","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura F.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."},{"name":"Corporal Michael J. 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