{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:30Z","timestamp":1792787610887,"version":"4.5.0"},"reference-count":41,"publisher":"American Society for Clinical Investigation","issue":"13","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["T32-CA244125,5U54CA254564,CA016086-46S3,R01 CA266544"],"award-info":[{"award-number":["T32-CA244125,5U54CA254564,CA016086-46S3,R01 CA266544"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,8]]},"abstract":"<jats:p>\n                    The most common subtype of lymphoma globally, diffuse large B cell lymphoma (DLBCL), is a leading cause of cancer death in people with HIV. The restructuring of the T cell compartment because of HIV infection and antiretroviral therapy (ART) may have implications for modern treatment selection, but current understanding of these dynamic interactions is limited. Here, we investigated the T cell response to DLBCL by sequencing the T cell receptor (TCR) repertoire in a cohort of HIV-negative (HIV\n                    <jats:sup>\u2013<\/jats:sup>\n                    ), HIV\n                    <jats:sup>+<\/jats:sup>\n                    \/ART-experienced, and HIV\n                    <jats:sup>+<\/jats:sup>\n                    \/ART-naive patients with DLBCL. HIV\n                    <jats:sup>+<\/jats:sup>\n                    \/ART-naive tumor TCR repertoires were more clonal and more distinct from each other than HIV\n                    <jats:sup>\u2013<\/jats:sup>\n                    and HIV\n                    <jats:sup>+<\/jats:sup>\n                    \/ART-experienced ones. Further, increased overlap between tumor and blood TCR repertoires was associated with improved survival and HIV\/ART status. Our study describes TCR repertoire characteristics for the first time to our knowledge in an African DLBCL cohort and demonstrates contributions of HIV infection and ART exposure to the DLBCL TCR repertoire.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.180771","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T14:00:27Z","timestamp":1720360827000},"source":"Crossref","is-referenced-by-count":7,"title":["HIV infection and ART exposure affect tumor TCR repertoire of diffuse large B cell lymphoma"],"prefix":"10.1172","volume":"9","author":[{"given":"Sophia M.","family":"Roush","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School 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