{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:10:32Z","timestamp":1793398232654,"version":"4.5.0"},"reference-count":54,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaison Committee for education, research, and innovation in Central Norway","award":["982147"],"award-info":[{"award-number":["982147"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,9]]},"abstract":"<jats:p>\n                    Overall survival (OS) in multiple myeloma (MM) varies between a couple of months to more than 20 years, influenced by tumor characteristics, the tumor microenvironment (TME), and patient factors such as age and frailty. We analyzed sequential BM samples from 45 MM patients with OS less than 3 years versus more than 8 years using mass cytometry and bulk TCR\u03b2 sequencing. Patients with long OS demonstrated stability in the TME and T cell environments, while those with short OS had significant changes at relapse, including fewer T cells, increased Tregs, and more activated and exhausted CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Notably, higher programmed cell death 1 expression in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells at diagnosis correlated with short OS. Additionally, short-OS patients exhibited a more monoclonal T cell environment at relapse, with abundance of hyperexpanded clones. These findings reveal distinct immune cell differences between patients with short and long OS.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.181096","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:33:04Z","timestamp":1745929984000},"source":"Crossref","is-referenced-by-count":1,"title":["T cell phenotype and clonality changes in myeloma patients with short overall survival"],"prefix":"10.1172","volume":"10","author":[{"given":"Alenka Djarmila","family":"Behsen","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway."},{"name":"Department of Hematology, St. Olavs Hospital, Trondheim, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esten Nymoen","family":"Vandsemb","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 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