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Here, we report that the membrane mucin MUC17 protected small intestinal enterocytes against commensal and pathogenic bacteria. In noninflamed CD ileum, reduced MUC17 levels and a compromised glycocalyx barrier allowed recurrent bacterial contact with enterocytes.\n                    <jats:italic>Muc17<\/jats:italic>\n                    deletion in mice rendered the small intestine particularly prone to atypical bacterial infection while maintaining resistance to colitis. The loss of Muc17 resulted in spontaneous deterioration of epithelial homeostasis and in the extraintestinal translocation of bacteria. Finally, Muc17-deficient mice harbored specific small intestinal bacterial taxa observed in patients with CD. Our findings highlight MUC17 as an essential region-specific line of defense in the small intestine with relevance for early epithelial defects in CD.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.181481","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:00:26Z","timestamp":1734609626000},"source":"Crossref","is-referenced-by-count":14,"title":["MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn\u2019s disease"],"prefix":"10.1172","volume":"10","author":[{"given":"Elena","family":"Layunta","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"J\u00e4verfelt","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur C.","family":"van de Koolwijk","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Sivertsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-0960","authenticated-orcid":true,"given":"Liisa","family":"Arike","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara I.M.","family":"Thulin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Vallance","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, BC Children\u2019s Hospital Research Institute, University of British Columbia, Vancouver, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaher","family":"Pelaseyed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12182"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00675-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803124105"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317571"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00046.2013"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275671"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00141.2013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20071068"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108757"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90025-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.054"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.061"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ng1954"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.028"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.02.022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200902147"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24148-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3791\/50222"},{"key":"B20","first-page":"355","article-title":"Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. 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