{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:46:18Z","timestamp":1792615578016,"version":"4.5.0"},"reference-count":72,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI18\/01532"],"award-info":[{"award-number":["PI18\/01532"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>We evaluated the safety and viral rebound, after analytical treatment interruption (ATI), of vedolizumab and ART in recent HIV-1 infection. We used this model to analyze the effect of \u03b14\u03b27 on the HIV-1 reservoir size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants started ART with monthly vedolizumab infusions, and ATI was performed at week 24. Biopsies were obtained from ileum and cecum at baseline and week 24. Vedolizumab levels, HIV-1 reservoir, flow cytometry, and cell-sorting and antibody competition experiments were assayed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Vedolizumab was safe and well tolerated. No participant achieved undetectable viremia off ART 24 weeks after ATI. Only a modest effect on the time to achieve more than 1,000 HIV-1 RNA copies\/mL and the proportion of participants off ART was observed, being higher in the vedolizumab group compared with historical controls. Just before ATI, \u03b14\u03b27 expression was associated with HIV-1 DNA and RNA in peripheral blood and with PD1 and TIGIT levels. Importantly, a complete blocking of \u03b14\u03b27 was observed on peripheral CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells but not in gut (ileum and cecum), where \u03b14\u03b27 blockade and vedolizumab levels were inversely associated with HIV-1 DNA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our findings support \u03b14\u03b27 as an important determinant in HIV-1 reservoir size, suggesting the complete \u03b14\u03b27 blockade in tissue as a promising tool for HIV-cure combination strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT03577782.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>This work was supported by the Instituto de Salud Carlos III (Fondo Europeo de Desarrollo Regional, \u201ca way to make Europe,\u201d research contracts FI17\/00186 and FI19\/00083 and research projects PI18\/01532, PI19\/01127, PI22\/01796), Conserjer\u00eda de Econom\u00eda, Conocimiento, Empresas y Universidad, Junta de Andaluc\u00eda (research projects P20\/00906), the Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en SIDA (RD16\/0025\/0020), and the Spanish National Research Council.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.182312","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T12:03:26Z","timestamp":1720526606000},"source":"Crossref","is-referenced-by-count":9,"title":["Vedolizumab and ART in recent HIV-1 infection unveil the role of \u03b14\u03b27 in reservoir 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