{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:53:24Z","timestamp":1793638404460,"version":"4.5.1"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82001019,82071091"],"award-info":[{"award-number":["82001019,82071091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["00403054A1188"],"award-info":[{"award-number":["00403054A1188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Department of Sichuan Province","award":["2022NSFSC0598"],"award-info":[{"award-number":["2022NSFSC0598"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>\n                    Bone contains multiple pools of skeletal stem\/progenitor cells (SSPCs), and SSPCs in periosteal compartments are known to exhibit higher regenerative potential than those in BM and endosteal compartments. However, the in vivo identity and hierarchical relationships of periosteal SSPCs (P-SSPCs) remain unclear due to a lack of reliable markers to distinguish BM SSPCs and P-SSPCs. Here, we found that periosteal mesenchymal progenitor cells (P-MPs) in periosteum can be identified based on\n                    <jats:italic>Postn<\/jats:italic>\n                    -CreER\n                    <jats:sup>T2<\/jats:sup>\n                    expression.\n                    <jats:italic>Postn<\/jats:italic>\n                    -expressing periosteal subpopulation produces osteolineage descendants that fuel bones to maintain homeostasis and support regeneration. Notably,\n                    <jats:italic>Postn<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    P-MPs are likely derived from\n                    <jats:italic>Gli1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    skeletal stem cells (SSCs). Ablation of\n                    <jats:italic>Postn<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    cells results in impairments in homeostatic cortical bone architecture and defects in fracture repair. Genetic deletion of\n                    <jats:italic>Igf1r<\/jats:italic>\n                    in\n                    <jats:italic>Postn<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    cells dampens bone fracture healing. In summary, our study provides a mechanistic understanding of bone regeneration through the regulation of region-specific\n                    <jats:italic>Postn<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    P-MPs.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.182524","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T14:00:37Z","timestamp":1728309637000},"source":"Crossref","is-referenced-by-count":18,"title":["Identification of Postn+ periosteal progenitor cells with bone regenerative potential"],"prefix":"10.1172","volume":"9","author":[{"given":"Bei","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases,"},{"name":"National Center for Stomatology,"},{"name":"National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,"},{"name":"Department of Endodontics, West China School of 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