{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:51:01Z","timestamp":1791949861139,"version":"4.3.4"},"reference-count":100,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Underwood Trust","award":["E113101-101"],"award-info":[{"award-number":["E113101-101"]}]},{"name":"NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology","award":["BRC4-03-RB414-405"],"award-info":[{"award-number":["BRC4-03-RB414-405"]}]},{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"crossref","award":["1444907"],"award-info":[{"award-number":["1444907"]}],"id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000305","name":"Sight Research UK","doi-asserted-by":"crossref","award":["GR3684"],"award-info":[{"award-number":["GR3684"]}],"id":[{"id":"10.13039\/501100000305","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,8]]},"abstract":"<jats:p>\n                    Recurrent acute anterior uveitis is a frequent extra-articular manifestation of the axial spondyloarthropathies (AxSpA): chronic inflammatory diseases affecting the spine, enthesis, peripheral joints, skin, and gastrointestinal tract. Pathology in AxSpA has been associated with local tissue-resident populations of IL-23 responsive lymphoid cells. Here we characterize a population of ocular T cell defined by CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2013<\/jats:sup>\n                    CD8\n                    <jats:sup>\u2013<\/jats:sup>\n                    CD69\n                    <jats:sup>+<\/jats:sup>\n                    \u03b3\u03b4TCR\n                    <jats:sup>+<\/jats:sup>\n                    IL-23R\n                    <jats:sup>+<\/jats:sup>\n                    that reside within the anterior uvea as an ocular entheseal analogue of the mouse eye. Localized cytokine expression demonstrates that uveal IL-23R\n                    <jats:sup>+<\/jats:sup>\n                    IL-17A\u2013producing cells are both necessary and sufficient to drive uveitis in response to IL-23. This T cell population is also present in humans, occupying extravascular tissues of the anterior uveal compartment. Consistent with the concept of IL-23 as a unifying mediator in AxSpA, we present evidence that IL-23 can also act locally on tissue resident T cells in the anterior compartment of the eye at sites analogous to the enthesis to drive ocular inflammation.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.182616","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:00:31Z","timestamp":1756396831000},"source":"Crossref","is-referenced-by-count":8,"title":["IL-23 drives uveitis by acting on a population of tissue-resident entheseal T cells"],"prefix":"10.1172","volume":"10","author":[{"given":"Robert","family":"Hedley","sequence":"first","affiliation":[{"name":"Botnar Research Centre, and"},{"name":"Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ward","sequence":"additional","affiliation":[{"name":"Academic Unit of Ophthalmology, 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