{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:07:19Z","timestamp":1787854039173,"version":"build-2784847793"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"9","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI143828"],"award-info":[{"award-number":["R01AI143828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI146031"],"award-info":[{"award-number":["R01AI146031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32AI007313"],"award-info":[{"award-number":["T32AI007313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:p>\n                    <jats:italic>P.falciparum<\/jats:italic>\n                    infection can trigger high levels of inflammation that lead to fever and sometimes severe disease. People living in malaria-endemic areas gradually develop resistance to symptomatic malaria and control both parasite numbers and the inflammatory response. We previously found that adaptive NK cells correlated with reduced parasite load and protection from symptoms. We also found that murine NK cell production of IL-10 protected mice from experimental cerebral malaria. Human NK cells can also secrete IL-10, but it is unknown what NK cell subsets produce IL-10 or if this is affected by malaria experience. We hypothesized that NK cell immunoregulation may lower inflammation and reduce fever induction. Here, we showed that NK cells from participants with malaria experience make significantly more IL-10 than participants with no malaria experience. We then determined the proportions of NK cells that are cytotoxic and produce IFN-\u03b3 and\/or IL-10 and identified a signature of adaptive and checkpoint molecules on IL-10\u2013producing NK cells. Lastly, we found that coculture with primary monocytes,\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    -infected RBCs, and antibody induced IL-10 production by NK cells. These data suggest that NK cells may contribute to protection from malaria symptoms via IL-10 production.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.183076","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T14:00:36Z","timestamp":1746626436000},"source":"Crossref","is-referenced-by-count":3,"title":["Phenotype and function of IL-10\u2013producing NK cells in individuals with malaria experience"],"prefix":"10.1172","volume":"10","author":[{"given":"Sarah A.","family":"McNitt","sequence":"first","affiliation":[{"name":"Department of Osteopathic Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna K.","family":"Dick","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Internal Medicine, Department of Medicine,"},{"name":"Center for Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Andrea","family":"Hernandez-Castaneda","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Internal Medicine, Department of Medicine,"},{"name":"Center for Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Sangala","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Internal Medicine, Department of Medicine,"},{"name":"Center for Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pierson","sequence":"additional","affiliation":[{"name":"Center for Immunology,"},{"name":"Department of Laboratory Medicine and Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Macchietto","sequence":"additional","affiliation":[{"name":"Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina S.","family":"Burrack","sequence":"additional","affiliation":[{"name":"Center for Immunology,"},{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-0412","authenticated-orcid":true,"given":"Peter D.","family":"Crompton","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Division of Intramural Research, National Institute of Allergy and Infectious Disease (NIAID), NIH, Rockville, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-9549","authenticated-orcid":true,"given":"Karl","family":"Seydel","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA."},{"name":"Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Center for Immunology,"},{"name":"Department of Laboratory Medicine and Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and Internal Medicine, Department of Medicine,"},{"name":"Center for Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00016-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120220"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1669415"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2021.111425"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312775"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36806"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181681"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.add9012"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-856831"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1086\/595295"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.009"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2023.126650"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005577"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abc9801"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-386995"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110900108"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203034"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit174"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis675"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025569"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900829"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005118"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80404-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1625"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.10.031"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300525"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4395"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009288"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004079"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23215"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00094"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1086\/314548"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.012"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00167"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071807"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00348-8"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2021-0232"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1829-2"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-18-0386"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150434"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03464.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0082-6"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01420-14"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006576"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01100-15"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005708"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020118"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00403"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109586"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507355102"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2014.09.019"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1086\/320999"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2390-0"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00104"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0710"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0285-6"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43181-7"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI153733"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw147"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv054"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nature10624"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2019.0129"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.06.004"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2658::AID-IMMU2658>3.0.CO;2-G"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.619195"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-360321"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adf2223"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0368-5"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-016-0955-9"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200488"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piae093.025"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2189-9_48"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1874-1"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/183076\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:43:43Z","timestamp":1779126223000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/183076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":77,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,4,8]]},"published-print":{"date-parts":[[2025,5,8]]}},"alternative-id":["10.1172\/jci.insight.183076"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.183076","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.11.593687","asserted-by":"object"}]},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"article-number":"e183076"}}