{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:44:33Z","timestamp":1793173473107,"version":"4.5.0"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.81873525"],"award-info":[{"award-number":["No.81873525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070491"],"award-info":[{"award-number":["82070491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Program of National Natural Science Foundation of China","award":["No.82202394"],"award-info":[{"award-number":["No.82202394"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,22]]},"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) is one of the most life-threatening cardiovascular diseases; however, effective drug treatments are still lacking. The formation of neutrophil extracellular traps (NETs) has been shown to be a crucial trigger of AAA, and identifying upstream regulatory targets is thus key to discovering therapeutic agents for AAA. We revealed that phosphoinositide-3-kinase \u03b3 (PI3K\u03b3) acted as an upstream regulatory molecule and that PI3K\u03b3 inhibition reduced NET formation and aortic wall inflammation, thereby markedly ameliorating AAA. However, the mechanism of NET formation regulated by PI3K\u03b3 remains unclear. In this study, we showed that PI3K\u03b3 deficiency inactivated the noncanonical pyroptosis pathway, which suppressed downstream NET formation. In addition, PI3K\u03b3 regulation of noncanonical pyroptosis was dependent on cyclic AMP\/protein kinase A signaling. These results clarify the molecular mechanism and crosstalk between PI3K\u03b3 and NETosis in the development of AAA, potentially facilitating the discovery of therapeutic options for AAA.<\/jats:p>","DOI":"10.1172\/jci.insight.183237","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:01:53Z","timestamp":1721304113000},"source":"Crossref","is-referenced-by-count":20,"title":["PI3K\u03b3 promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm"],"prefix":"10.1172","volume":"9","author":[{"given":"Yacheng","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 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