{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:29:24Z","timestamp":1794198564957,"version":"4.8.0"},"reference-count":92,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,22]]},"abstract":"<jats:p>\n                    Aberrant immune response is a hallmark of asthma, with 5%\u201310% of patients suffering from severe disease exhibiting poor response to standard treatment. A better understanding of the immune responses contributing to disease heterogeneity is critical for improving asthma management. T cells are major players in the orchestration of asthma, in both mild and severe disease, but it is unclear whether specific T cell subsets influence asthma symptom duration. Here we show a significant association of airway CD8\n                    <jats:sup>+<\/jats:sup>\n                    effector memory T cells re-expressing CD45RA (TEMRAs), but not CD8\n                    <jats:sup>+<\/jats:sup>\n                    CD45RO\n                    <jats:sup>+<\/jats:sup>\n                    or tissue-resident memory T cells, with asthma duration in patients with severe asthma (SA) but not mild to moderate asthma (MMA). Higher frequencies of IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    TEMRAs compared with IFN-\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    CD45RO\n                    <jats:sup>+<\/jats:sup>\n                    T cells were detected in SA airways, and the TEMRAs from patients with SA but not MMA proliferated ex vivo, although both expressed cellular senescence-associated biomarkers. Prompted by the transcriptomic profile of SA CD8\n                    <jats:sup>+<\/jats:sup>\n                    TEMRAs and proliferative response to IL-15, airway\n                    <jats:italic>IL15<\/jats:italic>\n                    expression was higher in patients with SA compared with MMA. Additionally,\n                    <jats:italic>IL15<\/jats:italic>\n                    expression in asthmatic airways negatively correlated with lung function. Our findings add what we believe is a new dimension to understanding asthma heterogeneity, identifying IL-15 as a potential target for treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.185061","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T12:00:50Z","timestamp":1741262450000},"source":"Crossref","is-referenced-by-count":9,"title":["CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest"],"prefix":"10.1172","volume":"10","author":[{"given":"Richard P.","family":"Ramonell","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine,"},{"name":"Asthma and Environmental Lung Health Institute at UPMC,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy B.","family":"Oriss","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care 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