{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:22:45Z","timestamp":1793146965569,"version":"4.5.0"},"reference-count":60,"publisher":"American Society for Clinical Investigation","issue":"3","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82203925"],"award-info":[{"award-number":["82203925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"crossref","award":["2024JC-YBMS-645"],"award-info":[{"award-number":["2024JC-YBMS-645"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases","award":["2023YF03"],"award-info":[{"award-number":["2023YF03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:p>\n                    Oral lichen planus (OLP) is a recalcitrant inflammatory disease with potential for malignant transformation, involving a cytotoxic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013mediated basal keratinocyte apoptosis. However, it lacks an appropriate mouse model for study. Here we developed an OLP-like mouse model using topical oxazolone to induce a delayed-type hypersensitivity-mediated oral lichenoid reaction. Histological and ultrastructural analysis confirmed hallmark pathological features of OLP, including band-like CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and basal cell damage as well as the presence of Civatte bodies. Comparative transcriptomic analysis revealed significant similarity between RNA-Seq profiles of the mouse model and human OLP lesions, highlighting shared upregulated genes and enriched pathways, particularly those related to IFN-\u03b3 signaling and cytotoxic T cell activity. Functional studies demonstrated that the OLP phenotype depended on IFN-\u03b3, with local priming by IFN-\u03b3 intensifying the disease through upregulation of major histocompatibility complex class I. Additionally, the absence of Langerhans cells exacerbated disease severity in vivo. Therapeutic evaluation showed that the JAK inhibitors baricitinib and ruxolitinib effectively reduced disease burden and provided mechanistic insights. In conclusion, this OLP-like mouse model recapitulates key immunopathological and transcriptomic features of human OLP, offering a robust platform for dissecting disease mechanisms and evaluating novel therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.185380","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:00:39Z","timestamp":1765472439000},"source":"Crossref","is-referenced-by-count":6,"title":["An oral lichen planus\u2013like mouse model driven by IFN-\u03b3 signaling and cytotoxic CD8+ T cells"],"prefix":"10.1172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-8222","authenticated-orcid":true,"given":"Zhenlai","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Oral medicine, School of Stomatology,"},{"name":"Department of Dermatology, Xijing Hospital,"},{"name":"Department of Microbiology & Pathogen Biology, School of Basic Medical Sciences,"},{"name":"Department of Transfusion Medicine, Xijing Hospital, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinglan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Oral medicine, School of Stomatology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical 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