{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:10:07Z","timestamp":1779138607877,"version":"3.51.4"},"reference-count":46,"publisher":"American Society for Clinical Investigation","issue":"5","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["(BAA) 75D301-20-R-67897"],"award-info":[{"award-number":["(BAA) 75D301-20-R-67897"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:p>\n                    The effect of preexisting neutralizing antibodies (NAb) on SARS-CoV-2 shedding in postvaccination infection (PVI) is not well understood. We characterized viral shedding longitudinally in nasal specimens in relation to baseline (pre\/periinfection) serum NAb titers in 125 participants infected with SARS-CoV-2 variants. Among 68 vaccinated participants, we quantified the effect of baseline NAb titers on maximum viral RNA titers and infectivity duration. Baseline NAbs were higher and targeted a broader range of variants in participants with monovalent ancestral booster vaccinations compared with those with a primary vaccine series. In Delta infections, baseline NAb titers targeting Delta or Wuhan-Hu-1 correlated negatively with maximum viral RNA. Per log\n                    <jats:sub>10<\/jats:sub>\n                    increase in Delta-targeting baseline NAb IC\n                    <jats:sub>50<\/jats:sub>\n                    , maximum viral load was reduced \u20132.43 (95% CI: \u20133.76, \u20131.11) log\n                    <jats:sub>10<\/jats:sub>\n                    nucleocapsid copies, and infectious viral shedding was reduced \u20132.79 (95% CI: \u20134.99, \u20130.60) days. Conversely, in Omicron infections (BA.1, BA.2, BA.4, or BA.5), baseline NAb titers against Omicron lineages or Wuhan-Hu-1 did not predict viral outcomes. Our results provide robust estimates of the effect of baseline NAbs on the magnitude and duration of nasal viral replication after PVI (albeit with an unclear effect on transmission) and show how immune escape variants efficiently evade these modulating effects.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.185953","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T14:00:53Z","timestamp":1741528853000},"source":"Crossref","is-referenced-by-count":0,"title":["Circulating neutralizing antibodies and SARS-CoV-2 variant replication following postvaccination infections"],"prefix":"10.1172","volume":"10","author":[{"given":"Miguel A.","family":"Garcia-Knight","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, UCSF, San Francisco, California, USA."},{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-0321","authenticated-orcid":true,"given":"J. 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