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The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which resembles human placentation.\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    is expressed in multiple trophoblast cell lineages, including invasive trophoblast cells situated within the uterine-placental interface of the rat placentation site. Global genome editing was used to explore the biology of\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    in rat placenta development. Homozygous global disruption of\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    resulted in prenatal lethality. Heterozygous global disruption of\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    was associated with diminished invasive trophoblast cell infiltration into the uterus. The role of TFAP2C in the invasive trophoblast cell lineage was explored using Cre-lox conditional mutagenesis. Invasive trophoblast cell\u2013specific disruption of\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    resulted in inhibition of intrauterine trophoblast cell invasion and intrauterine and postnatal growth restriction. The invasive trophoblast cell lineage was not impaired following conditional monoallelic disruption of\n                    <jats:italic>Tfap2c<\/jats:italic>\n                    . In summary, TFAP2C contributes to the progression of distinct stages of placental development. TFAP2C is a driver of early events in trophoblast cell development and reappears later in gestation as an essential regulator of the invasive trophoblast cell lineage. A subset of TFAP2C actions on trophoblast cells are dependent on gene dosage.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.186471","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T12:00:27Z","timestamp":1733227227000},"source":"Crossref","is-referenced-by-count":7,"title":["TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation"],"prefix":"10.1172","volume":"10","author":[{"given":"Esteban M.","family":"Dominguez","sequence":"first","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-6475","authenticated-orcid":true,"given":"Ayelen","family":"Moreno-Irusta","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, 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