{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:09:25Z","timestamp":1793520565145,"version":"4.5.0"},"reference-count":43,"publisher":"American Society for Clinical Investigation","issue":"20","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,23]]},"abstract":"<jats:p>\n                    Recent experimental and epidemiologic data have strongly associated air pollution in the pathogenesis of insulin resistance and type 2 diabetes mellitus. We explored the effect of inhalational exposure to concentrated ambient particulate matter smaller than 2.5 \u03bcm (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ), or filtered air, using a whole-body inhalation system (6 hours\/day, 5 days\/week) for 24 weeks on metabolism and brown adipose tissue (BAT) function. Mechanistic evaluation of insulin resistance, glucose uptake with\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose positron emission tomography, alongside evaluation for differentially methylated regions, chromatin accessibility, and differential expression of genes was performed. PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure impaired metabolism through changes in key BAT transcriptional programs involved in redox stress, lipid deposition, fibrosis, and altered thermogenesis. Significant differential methylation and widespread chromatin remodeling was noted in BAT with PM\n                    <jats:sub>2.5<\/jats:sub>\n                    . Integrated analysis uncovered a role for the histone deacetylase HDAC9 and histone demethylase KDM2B. The latter demethylates Lys-4 and Lys-36 of histone H3. Specifically, studies using ChIP combined with quantitative PCR confirmed HDAC9 and KDM2B occupancy and reduced H3K36me2 on the promoter of target BAT genes in PM\n                    <jats:sub>2.5<\/jats:sub>\n                    mice, while\n                    <jats:italic>Hdac9\/Kdm2b<\/jats:italic>\n                    knockdown and overexpression increased and reduced BAT metabolism, respectively. Collectively, our results provide insights into air pollution exposure and changes in BAT and metabolism.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.187023","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:00:46Z","timestamp":1758564046000},"source":"Crossref","is-referenced-by-count":3,"title":["Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B"],"prefix":"10.1172","volume":"10","author":[{"given":"Rengasamy","family":"Palanivel","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Eudes","family":"Dazard","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Costantino","sequence":"additional","affiliation":[{"name":"Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland."},{"name":"University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skanda T.","family":"Moorthy","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Vergara-Martel","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Ann","family":"Cara","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonnelle","family":"Edwards-Glenn","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Biswal","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paneni","sequence":"additional","affiliation":[{"name":"Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland."},{"name":"University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-8163","authenticated-orcid":true,"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA."},{"name":"Harrington Heart and Vascular Institute, University Hospitals, Cleveland, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00361-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(22)00122-X"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137315"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw294"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0603-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-014-0053-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306841"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0190"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature21363"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature04634"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-052220-010446"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.11.002"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322135"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101728"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0350-5"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10487-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.121.211801"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.03.071"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1779209"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr211"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-8-20"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/JP273282"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2492063"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1630"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05184-5"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2307\/1269659"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02705"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13016"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.005"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-0652"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0617-7"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00562-17"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00257"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgab065"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1148"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.677930"},{"issue":"8","key":"B38","first-page":"2222","article-title":"The critical role of histone lysine demethylase KDM2B in cancer","volume":"10","author":"Yan","year":"2018","journal-title":"Am J Transl Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04127-6"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz607"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9073"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0382-4"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.10.017"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/187023\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:20:10Z","timestamp":1779124810000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/187023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":43,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10,8]]},"published-print":{"date-parts":[[2025,10,8]]}},"alternative-id":["10.1172\/jci.insight.187023"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.187023","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"article-number":"e187023"}}