{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:45:59Z","timestamp":1792640759726,"version":"4.5.0"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["U19AI144181,R01AI170959,T32AI007001"],"award-info":[{"award-number":["U19AI144181,R01AI170959,T32AI007001"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002570","name":"American Association of Immunologists","doi-asserted-by":"crossref","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100002570","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:p>\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    (CT) is the most common bacterial sexually transmitted infection globally. Understanding natural immunity to CT will inform vaccine design. This study aimed to profile immune cells and associated functional features in CT-infected women and determine immune profiles associated with reduced risk of ascended endometrial CT infection and CT reinfection. PBMCs from CT-exposed women were profiled by mass cytometry, and random forest models identified key features that distinguished outcomes. CT+ participants exhibited higher frequencies of CD4\n                    <jats:sup>+<\/jats:sup>\n                    Th2, Th17, and Th17 double-negative (Th17 DN) CD4\n                    <jats:sup>+<\/jats:sup>\n                    T effector memory (TEM) cells than uninfected participants with decreased expression of T cell activation and differentiation markers. Minimal differences were detected between women with or without endometrial CT infection. Participants who remained follow-up negative (FU\u2013) showed higher frequencies of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T central memory (TCM) Th1, Th17, Th1\/17, and Th17 DN but reduced CD4\n                    <jats:sup>+<\/jats:sup>\n                    TEM Th2 cells than FU+ participants. Expression of markers associated with central memory and Th17 lineage was increased on T cell subsets among FU\u2013 participants. These data indicate that peripheral T cells exhibit distinct features associated with resistance to CT reinfection. The highly plastic Th17 lineage appears to contribute to protection. Addressing these immune nuances could promote efficacy of CT vaccines.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.189388","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T12:00:30Z","timestamp":1740657630000},"source":"Crossref","is-referenced-by-count":9,"title":["T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort"],"prefix":"10.1172","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-0164","authenticated-orcid":true,"given":"Kacy S.","family":"Yount","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4529-1645","authenticated-orcid":true,"given":"Chi-Jane","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computer Science; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Kollipara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha V.","family":"Mokashi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-933X","authenticated-orcid":true,"given":"Xiaojing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine;"},{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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