{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:05:00Z","timestamp":1793412300266,"version":"4.5.0"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82270769,82570804,32141005,82030025,82203636,82405111"],"award-info":[{"award-number":["82270769,82570804,32141005,82030025,82203636,82405111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Natural Science Foundation","award":["7242033"],"award-info":[{"award-number":["7242033"]}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"crossref","award":["20250484781"],"award-info":[{"award-number":["20250484781"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hainan Province Clinical Medical Center","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"Sanya Science and Technology Innovation Special Project","award":["2022KJCX02"],"award-info":[{"award-number":["2022KJCX02"]}]},{"name":"Youth Self-Innovation Science Foundation","award":["2024-HNYY-CZ-01"],"award-info":[{"award-number":["2024-HNYY-CZ-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,23]]},"abstract":"<jats:p>\n                    Heat stroke (HS) is the most severe heat-related emergency, and its pathophysiology remains largely unknown, especially for exertional HS (EHS), which affects younger populations, athletes, and manual workers. Herein, we performed single-cell-transcriptomics, T cell receptor sequencing, and flow cytometry of PBMCs from 9 healthy control participants, 9 patients with heat exhaustion, and 9 patients with EHS to explore complex immunological responses associated with HS pathobiology. We showcased that granzyme-positive T cells and CD56\n                    <jats:sup>dim<\/jats:sup>\n                    NK cells with high cytotoxicity features and IL-1B\n                    <jats:sup>+<\/jats:sup>\n                    NLRP3\n                    <jats:sup>+<\/jats:sup>\n                    monocytes with high inflammation and pyroptosis scores were enriched in HS, while the CD161\n                    <jats:sup>+<\/jats:sup>\n                    T cells with innate immune-like, low cytotoxicity, and clonal expansion features were reduced in HS. Importantly, elevated granzyme-positive T and NK cells might interact with monocytes to induce pyroptosis of hepatic and renal cells and target organ injuries, and blocking the NLRP3 inflammasome pathway prior to the induction could alleviate organ injury in HS. This study offers deeper insights into the pathogenesis of HS, supporting the development of optimal treatment strategies.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.189825","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:53:40Z","timestamp":1774284820000},"source":"Crossref","is-referenced-by-count":3,"title":["Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke"],"prefix":"10.1172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-5475","authenticated-orcid":true,"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Province Chen Xiangmei Academician Team Innovation Center for Kidney Diseases Research, Sanya, China."},{"name":"Senior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Province Chen Xiangmei Academician Team Innovation Center for Kidney Diseases Research, Sanya, China."},{"name":"Senior Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Province Chen Xiangmei Academician Team Innovation Center for Kidney Diseases Research, Sanya, 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