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Blocking expression of\n                    <jats:italic>Slfn5<\/jats:italic>\n                    in PDAC enhanced IFN responses, suppressed tumor growth, and prolonged survival in immunocompetent mice. Notably, immunophenotypic analysis revealed a reduction in tumor-associated macrophages alongside an increase in tumor-infiltrating effector cells in tumors over time. These findings suggest SLFN5 acts as an intracellular immune checkpoint and identify it as a unique therapeutic target for the development of therapies for PDAC and possibly other malignancies.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.190031","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:00:27Z","timestamp":1769533227000},"source":"Crossref","is-referenced-by-count":1,"title":["Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma"],"prefix":"10.1172","volume":"11","author":[{"given":"Mariafausta","family":"Fischietti","sequence":"first","affiliation":[{"name":"Robert H. 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