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However, effects of irradiation on senescence and SASP in human tissue and in the context of particle radiotherapy remain unclear. Here, we analyzed chemokine patterns after radiotherapy of human pancreatic tumors and cancer cell lines. We show that irradiated tumor cells coexpressed SASP chemokines in defined modules. These chemokine modules correlated with infiltration of distinct leukocyte subtypes expressing cognate receptors. We developed a patient-derived pancreatic tumor explant system, which verified our identified radiation-induced chemokine modules. Chemokine modules were partially conserved in cancer cells in response to photon and particle irradiation, showing a dose-dependent plateau effect, and induced subsequent migration of NK and T cell populations. Hence, our work reveals redundant interactions of cancer cells and immune cells in human tissue, suggesting that targeting multiple chemokines is required to efficiently perturb leukocyte infiltration after photon or particle radiotherapy.<\/jats:p>","DOI":"10.1172\/jci.insight.190149","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T16:00:34Z","timestamp":1755187234000},"source":"Crossref","is-referenced-by-count":4,"title":["Photon and particle radiotherapy induce redundant modular chemotaxis of human lymphocytes"],"prefix":"10.1172","volume":"10","author":[{"given":"Joscha A.","family":"Kraske","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, National Center for Tumor Diseases (NCT), and"},{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany."},{"name":"Division of Molecular and Radiooncology, German Cancer Research Center 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