{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:03:33Z","timestamp":1794006213542,"version":"4.8.0"},"reference-count":42,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R42 AI155275"],"award-info":[{"award-number":["R42 AI155275"]}]},{"name":"NIH","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,22]]},"abstract":"<jats:p>Yellow fever virus (YFV) infection is fatal in 5%\u201310% of the 200,000 yearly cases. There is currently no available antiviral treatment. We showed previously that administration of 50 mg\/kg of a YFV-specific neutralizing monoclonal antibody (nmAb) at 2 days postinfection (dpi), prior to the onset of severe disease, protected YFV-infected rhesus macaques from death. To further explore the clinical applicability of our nmAb MBL-YFV-01, we treated rhesus macaques with a lower dose (10 mg\/kg) of this nmAb prophylactically or therapeutically at 3.5 dpi. We show that a single prophylactic or therapeutic i.v. dose of our nmAb protects rhesus macaques from death following challenge. A comprehensive analysis of 167 inflammatory cytokine and chemokines revealed that protection was associated with significantly reduced expression of 125 of these markers, including type I IFN, IL-6, and CCL2. This study further expands the potential clinical use of our YFV-specific nmAb, which could be used during an outbreak for immediate prophylactic immunity or for patients with measurable serum viremia.<\/jats:p>","DOI":"10.1172\/jci.insight.191665","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:00:34Z","timestamp":1752595234000},"source":"Crossref","is-referenced-by-count":3,"title":["Prophylactic and therapeutic neutralizing monoclonal antibody treatment prevents lethal yellow fever infection"],"prefix":"10.1172","volume":"10","author":[{"given":"Lauren N.","family":"Rust","sequence":"first","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Mabloc LLC, Washington DC, USA."},{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah S.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiya","family":"Yusova","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan J.","family":"Louw","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Yrizarry-Medina","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreya","family":"Biswas","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Fischer","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Barber-Axthelm","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Zilverberg","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Bailey","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Swanson","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Tonelli","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.W.","family":"McElfresh","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon C.","family":"Rosen","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Voigt","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christakis","family":"Panayiotou","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T.","family":"Mauter","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Ghosh","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Meanor","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana","family":"Godoy","sequence":"additional","affiliation":[{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-5906","authenticated-orcid":true,"given":"Michael","family":"Axthelm","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."},{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Smedley","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."},{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Slifka","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esper G.","family":"Kallas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."},{"name":"Butantan Institute, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Webb","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zweig","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-6242","authenticated-orcid":true,"given":"Caralyn S.","family":"Labriola","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-3080","authenticated-orcid":true,"given":"Benjamin N.","family":"Bimber","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah B.","family":"Sacha","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."},{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Mabloc LLC, Washington DC, USA."},{"name":"George Washington University, Washington DC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Burwitz","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Beaverton, Oregon, USA."},{"name":"Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"B1","unstructured":"World Health Organization. Yellow fever. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/yellow-fever Accessed July 7, 2025"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2024.2369377"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-020-00293-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.05.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2018.1406800"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11020445"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.078"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.09-0295"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.12.047"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz374"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-017-0566-9"},{"key":"B12","unstructured":"Centers for Disease Control and Prevention. Yellow Fever. https:\/\/archive.cdc.gov\/www_cdc_gov\/globalhealth\/newsroom\/topics\/yellowfever\/index.html Accessed July 7, 2025"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-3527(03)60009-6"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108233"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1162342"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000226"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade5795"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003295"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.12.018"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30125-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2024.100737"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109321"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1086\/425016"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42834-x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812431"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13673"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014096117"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02180"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR1118-460R"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/life11070717"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1086\/320200"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760190033"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70099"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.AID-0022-2014"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45806-x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfab006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00753-5"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"B40","unstructured":"R: The R Project for Statistical Computing. https:\/\/www.r-project.org\/ Accessed July 7, 2025"},{"key":"B41"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/191665\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T15:08:47Z","timestamp":1779030527000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/191665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":42,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8,22]]},"published-print":{"date-parts":[[2025,8,22]]}},"alternative-id":["10.1172\/jci.insight.191665"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.191665","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"article-number":"e191665"}}