{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:57:18Z","timestamp":1793642238810,"version":"4.5.1"},"reference-count":64,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GIF-NC R\u00e9gion Nomandie","award":["no number"],"award-info":[{"award-number":["no number"]}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"crossref","award":["PhD grant Visio"],"award-info":[{"award-number":["PhD grant Visio"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,8]]},"abstract":"<jats:p>\n                    High myopia (HM) and posterior staphyloma (PS) are major causes of vision loss worldwide. Genetic and environmental factors, especially light exposure, influence myopia. This study shows that low-density lipoprotein\u2013related receptor type 2 (LRP2) levels are decreased in the vitreous of patients with HM and PS, and that in human donor eyes affected by PS, LRP2 expression was reduced in the neural retina and retinal pigment epithelium (RPE), with morphologic changes similar to those observed in the\n                    <jats:italic>Foxg1-Cre<\/jats:italic>\n                    -\n                    <jats:italic>\n                      Lrp2\n                      <jats:sup>fl\/fl<\/jats:sup>\n                    <\/jats:italic>\n                    mouse that also develops PS. In human induced pluripotent stem cell\u2013derived RPE cells, LRP2 silencing regulated genes involved in eye and neuronal development, visual perception, tissue remodeling, hormone metabolism, and RPE structure. Its expression increased under light exposure, particularly red light, but was downregulated by cortisol. These findings establish a link between LRP2, myopization, and environmental factors, highlighting its crucial role in nonsyndromic HM and PS. LRP2 appears to be a promising therapeutic target for HM treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.192929","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:00:27Z","timestamp":1750766427000},"source":"Crossref","is-referenced-by-count":5,"title":["LRP2 is a potential molecular target for nonsyndromic pathological myopia"],"prefix":"10.1172","volume":"10","author":[{"given":"Kimberley","family":"Delaunay","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, INSERM, Universit\u00e9 de Paris Cit\u00e9, Paris F-75006, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-0510","authenticated-orcid":true,"given":"Emilie","family":"Picard","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, INSERM, Universit\u00e9 de Paris Cit\u00e9, Paris F-75006, 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