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The understanding of how liquid is secreted in the lung is derived largely from studies of the airway epithelium. Comparatively little is known about liquid secretion mechanisms in the alveolar epithelium, including its cellular source. To define which cell type drives alveolar liquid secretion, we generated transgenic mice that expressed a\n                    <jats:italic>Cftr-<\/jats:italic>\n                    null allele in alveolar type 1 (AT1) cells, type 2 (AT2) cells, or both, then viewed liquid secretion in live alveoli using confocal microscopy of isolated, perfused lungs. Our findings show that liquid secretion was blocked in alveoli of all 3 transgenic mice, indicating that both AT1 and AT2 cells contribute to alveolar liquid secretion.\n                    <jats:italic>Cftr-<\/jats:italic>\n                    null expression in AT1 cells also blocked the secretion-mediated clearance of small particle and bacterial clusters from alveolar walls, indicating that AT1 cell CFTR contributes to alveolar defense. Together, these findings show alveolar liquid secretion depends on both AT1 and AT2 cell CFTR, and that CFTR in AT1 cells \u2014 a cell type not traditionally considered in liquid secretion mechanisms or CFTR-related lung diseases \u2014 contributes to lung liquid dynamics and host defense.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.194121","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:00:26Z","timestamp":1786464026000},"source":"Crossref","is-referenced-by-count":0,"title":["CFTR in alveolar type 1 cells contributes to lung liquid secretion and host defense"],"prefix":"10.1172","volume":"11","author":[{"given":"Sayahi","family":"Suthakaran","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, and"},{"name":"Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, 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