{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:32:24Z","timestamp":1791484344520,"version":"4.3.4"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21NS120003,R01NS134885"],"award-info":[{"award-number":["R21NS120003,R01NS134885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:p>Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Timely and continuous assessment of GBM progression is critical to expedite secondary surgery or enrollment in clinical trials. However, current progression detection requires costly and specialized MRI examinations, which, in the absence of new symptoms or signs, are usually scheduled every 2\u20133 months. Here, we hypothesized that changes in daily activity are associated with GBM growth and disease progression. We found that wheel-running activity in GBM-bearing mice declined as tumors grew and preceded weight loss and circadian breakdown by over a week. Temozolomide treatment in the morning, but not evening, significantly reduced tumor size and restored daily locomotion in mice. In a pilot study of 6 patients with GBM wearing an actigraphy watch, wrist movement provided a feasible and continuous longitudinal indicator of daily activity with 1-minute resolution. After tumor resection and radiation, daily activity declined in 2 patients 19 and 55 days before detection of progression by MRI but did not change for the 4 patients with stable disease. These results suggest that daily activity tracking using wearable devices may serve as a real-time indicator and potential monitoring tool for GBM progression and treatment efficacy.<\/jats:p>","DOI":"10.1172\/jci.insight.194582","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:00:37Z","timestamp":1764090037000},"source":"Crossref","is-referenced-by-count":1,"title":["Daily locomotor activity declines with tumor growth and disease progression in glioblastoma"],"prefix":"10.1172","volume":"11","author":[{"given":"Maria F.","family":"Gonzalez-Aponte","sequence":"first","affiliation":[{"name":"Department of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia V.","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Damato","sequence":"additional","affiliation":[{"name":"Department of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth G.N.","family":"Katumba","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grayson R.","family":"Talcott","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-3673","authenticated-orcid":true,"given":"Omar H.","family":"Butt","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian L.","family":"Campian","sequence":"additional","affiliation":[{"name":"Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-3072","authenticated-orcid":true,"given":"Jingqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery,"},{"name":"Siteman Cancer Center Biostatistics and Qualitative Research Shared Resource,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, St. Louis Children\u2019s Hospital, and"},{"name":"Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J.","family":"Walch","sequence":"additional","affiliation":[{"name":"Arcascope Inc., Arlington, Virginia, USA."},{"name":"Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik D.","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","unstructured":"Tamimi\n              AF\n            \n            \n              Juweid\n              M\n            \n          \n          Epidemiology and Outcome of Glioblastoma\n          Glioblastoma [Internet]\n          Codon Publications; 2017: Chapter 8."},{"key":"B2","unstructured":"National Cancer Institute. SEER Program. Cancer of the Brain and Other Nervous System - Cancer Stat Facts. https:\/\/seer.cancer.gov\/statfacts\/html\/brain.html Accessed November 21, 2025"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305-5839.2015.05.10"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1188\/16.CJON.S1.2-8"},{"key":"B5","unstructured":"MedScape. Glioblastoma (Multiforme) Imaging. https:\/\/emedicine.medscape.com\/article\/340870-overview Updated June 14, 2022. Accessed November 21, 2025"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou304"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3747\/co.v13i6.107"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now119"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e14036"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2021.62.376"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12124058"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/JNN.0000000000000088"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/jlme.12133"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npv020"},{"key":"B15","article-title":"Current Standards of Care in Glioblastoma Therapy","author":"Fernandes","journal-title":"Glioblastoma [Internet]"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.18718"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou087"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.02.002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605642"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3182467bb1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/0023677219883319"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65783-7"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2024.104058"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa180"},{"issue":"1","key":"B26","article-title":"Wearable sensors for activity monitoring and motion control: a review","volume":"3","author":"Wang","year":"2023","journal-title":"BIROB"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3642"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020503"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28020113"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad210"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951518001074"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.11.012"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1930-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2022.08.005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao5253"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-023-04535-9"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npac003"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1177\/07487304251336826"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0251-4"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020443"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx103"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3171\/2022.12.JNS222173"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.1373"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194798"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab126"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaf011"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03475-9"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.68921"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18803948"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143327"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00327"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06036-1"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13668"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-024-00412-y"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0370-8"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.855587"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1129-1"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox019"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdab041"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npaf006"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2018.10.004"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3490"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2174\/18756190MTA21MjAf3"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1464595"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71048"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9400-9"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1177\/0748730419878298"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03171-4"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/194582\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:31:46Z","timestamp":1778873506000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/194582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,9]]},"published-print":{"date-parts":[[2026,1,9]]}},"alternative-id":["10.1172\/jci.insight.194582"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.194582","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"e194582"}}