{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:13Z","timestamp":1792787653915,"version":"4.5.0"},"reference-count":95,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diabetes Research Connection","award":["no number provided"],"award-info":[{"award-number":["no number provided"]}],"id":[{"id":"https:\/\/ror.org\/01ef6m389","id-type":"ROR","asserted-by":"crossref"}]},{"name":"UAB AMC21 Multi-investigator grant","award":["no number provided"],"award-info":[{"award-number":["no number provided"]}]},{"name":"National Institutes of Health","award":["TL1TR003106,T32GM8111,F31HL167626,R25DK115353,K99HL165091,R01DK126664,K01HL145324,U24DK132740,P01HL158500,P30CA013148,S10OD028498,R01CA279143,R01DK134562"],"award-info":[{"award-number":["TL1TR003106,T32GM8111,F31HL167626,R25DK115353,K99HL165091,R01DK126664,K01HL145324,U24DK132740,P01HL158500,P30CA013148,S10OD028498,R01CA279143,R01DK134562"]}]},{"name":"Hirshberg Foundation Seed Award","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"https:\/\/ror.org\/03ayy2w09","id-type":"ROR","asserted-by":"crossref"}]},{"name":"voucher award from the UAB O\u2019Neal Comprehensive Cancer Center","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"https:\/\/ror.org\/03j18km61","id-type":"ROR","asserted-by":"crossref"}]},{"name":"voucher award from the UAB Flow Cytometry Core","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"National Institutes of Health","award":["T32 HL007457"],"award-info":[{"award-number":["T32 HL007457"]}]},{"name":"National Institutes of Health","award":["R25DK115353"],"award-info":[{"award-number":["R25DK115353"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:p>\n                    Obesity is a major risk factor for chronic kidney disease. Time-restricted feeding (TRF) shows promise to reduce kidney inflammation in chronic kidney disease. We hypothesized that TRF blunts kidney fibrosis in obese mice by mitigating T cell inflammation. We used a diet-induced obese mouse model fed a high-fat diet (DIO; 45% fat) ad libitum for 18 weeks followed by 2 weeks of TRF or ad libitum high-fat feeding. We found that TRF reversed kidney fibrosis as well as reduced kidney CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in DIO mice. Our study also reveals that DIO mice had increased kidney CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration from the small intestine that was blunted with TRF. Furthermore, anti-CD8 intervention in DIO showed reduced kidney fibrosis and damage compared with anti-IgG\u2013treated DIO mice. Single-cell RNA-seq data reveal that DIO increased, while TRF reduced, the frequency of a specific cluster of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells that featured high expression of exhaustion\/activation genes. Spatial analyses showed DIO mice had significant infiltration of PD-1\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells near CD31\n                    <jats:sup>+<\/jats:sup>\n                    endothelial cells that was diminished by TRF. In conclusion, this study shows that TRF reversed kidney fibrosis through reducing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration in obese mice.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.195335","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:49:56Z","timestamp":1787942996000},"source":"Crossref","is-referenced-by-count":0,"title":["Time-restricted feeding reverses kidney fibrosis through reducing CD8+ T cell infiltration in obese mice"],"prefix":"10.1172","volume":"11","author":[{"given":"Claudia J.","family":"Edell","sequence":"first","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah C.","family":"Walker","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Colson","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heim","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Nagila","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-8205","authenticated-orcid":true,"given":"Kyle H.","family":"Moore","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri M.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8465-2588","authenticated-orcid":true,"given":"Kelly","family":"Hyndman","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-6964","authenticated-orcid":true,"given":"Selene","family":"Meza-Perez","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology & Rheumatology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy D.","family":"Randall","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology & Rheumatology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annye P.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna G.","family":"Sorace","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua Dean","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Radiology,"},{"name":"Department of Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"De Miguel","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julienne L.","family":"Carstens","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Cardio-Renal Physiology & Medicine,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23614"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.004"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.160257"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76327"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14037"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320373"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba4163"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120859"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.160345"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.9.4454"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.12.011"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113963"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00335.2011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.51126"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1663251"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.020"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqaf001"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.03.001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.606441"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nature24628"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-9-49"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.06.025"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103764"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.007"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243884"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.01.022"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01040-x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139793"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20514"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113780"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.924541"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24734-0"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1040233"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2811"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.10.002"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1072288"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-00667-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.4.568"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00529.2016"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00008.2006"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.02.015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132569"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.03.030"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.008"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106311"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516485113"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070990"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.05.020"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010001"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501232"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04147"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13190"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.09.010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21737-9"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.11.012"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35238-w"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.197442"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1506"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.04.008"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.4203"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1457"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0221-9"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.09.001"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2021.11.003"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000725"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05388-4"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103409"},{"key":"B71","doi-asserted-by":"crossref","unstructured":"Taniguchi K, et al. Targeting CD153+PD-1+CD4+ senescence-associated T cells ameliorates kidney damage by attenuating tertiary lymphoid structure formation. Paper presented at: American Society of Nephrology Kidney Week 2024; October 23\u201327, 2024; San Diego, California, USA. https:\/\/www.asn-online.org\/education\/kidneyweek\/2024\/program-abstract.aspx?controlId=4128057 Accessed August 21, 2026","DOI":"10.1681\/ASN.2024xgq2wfk5"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01410"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51186-z"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62599-9"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305697"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00289.2017"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-026-01504-0"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256682"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2024.107646"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-6262-3"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016455"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030470"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00047.2024"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065806"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.09.108"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2328320"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110797"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nri2515"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-8-11"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-023-00580-1"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2025.40.S1.1782"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0869"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.198.Supp.74.7"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00659"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046057"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/195335\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:01:06Z","timestamp":1791396066000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/195335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":95,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,8,18]]},"published-print":{"date-parts":[[2026,10,8]]}},"alternative-id":["10.1172\/jci.insight.195335"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.195335","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"e195335"}}