{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T15:08:33Z","timestamp":1779030513219,"version":"3.51.4"},"reference-count":84,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["K01DK114372,P30DK98722,P30DK63608,P30DK116074"],"award-info":[{"award-number":["K01DK114372,P30DK98722,P30DK63608,P30DK116074"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,8]]},"abstract":"<jats:p>\n                    Obesity and type 2 diabetes (T2D) are metabolic diseases with increasing prevalence worldwide. Obesity often leads to T2D. Insulin resistance and impaired \u03b2 cell function contribute to the onset of hyperglycemia. Previously, we reported that ablation of\n                    <jats:italic>Gc<\/jats:italic>\n                    , encoding a secreted protein with a primary role in vitamin D transport, improved pancreatic \u03b2 cell function in models of diet-induced insulin resistance. Here, we show that\n                    <jats:italic>Gc<\/jats:italic>\n                    ablation had systemic insulin-sensitizing effects to prevent weight gain, hyperglycemia, and glucose intolerance; lower nonesterified fatty acids and triglycerides; and augment glucose uptake in skeletal muscle and adipose in male mice fed a high-fat diet. Interestingly, weight loss in\n                    <jats:italic>Gc<\/jats:italic>\n                    -ablated mice resulted from selective fat mass loss with preserved lean mass. Moreover, acute\n                    <jats:italic>Gc<\/jats:italic>\n                    inhibition prevented glucose intolerance caused by high-fat feeding. The data suggest that\n                    <jats:italic>Gc<\/jats:italic>\n                    inhibition can increase insulin production in \u03b2 cells and insulin action in peripheral tissues, while reducing fat mass.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.195341","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T19:00:36Z","timestamp":1765134036000},"source":"Crossref","is-referenced-by-count":2,"title":["Gc inhibition preserves insulin sensitivity and reduces body weight without loss of muscle 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