{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:17:47Z","timestamp":1791415067049,"version":"4.3.3"},"reference-count":40,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["Postdoctoral Fellowship Program of CPSF under Grant Number GZC20241551,"],"award-info":[{"award-number":["Postdoctoral Fellowship Program of CPSF under Grant Number GZC20241551,"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["the fellowship of China Postdoctoral Science Foundation under Grant Number 2022T150593."],"award-info":[{"award-number":["the fellowship of China Postdoctoral Science Foundation under Grant Number 2022T150593."]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:p>Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was assessed in human atrial samples and angiotensin II\u2013treated (Ang II\u2013treated) mouse atrial tissues. An Ang II\u2013induced AF mouse model was employed to investigate the effects of USP10 on atrial remodeling and AF susceptibility. Calcium imaging and patch clamp techniques were used to evaluate USP10\u2019s influence on calcium handling and triggered activity. Additionally, RNA sequencing, coimmunoprecipitation, and ubiquitination assays were performed to explore the regulatory interactions between USP10 and NADH:ubiquinone oxidoreductase subunit S1 (NDUFS1). Our findings demonstrate that USP10 is downregulated in atrial tissues from mouse models and patients with AF. USP10 overexpression counteracts Ang II\u2013induced atrial remodeling and reduces AF susceptibility. Furthermore, USP10 contributes to the restoration of mitochondrial function in AF. Mechanistically, USP10 deubiquitinates NDUFS1 at lysine 621, stabilizing NDUFS1 protein levels and mitigating Ang II\u2013induced mitochondrial dysfunction. This study uncovers a critical mechanistic link between USP10 and NDUFS1. Our findings suggest that upregulating USP10 or targeting NDUFS1 degradation could provide an alternative therapeutic strategy to mitigate AF progression and associated cardiovascular risk.<\/jats:p>","DOI":"10.1172\/jci.insight.195761","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:01:06Z","timestamp":1787508066000},"source":"Crossref","is-referenced-by-count":1,"title":["USP10 mitigates Ang II\u2013induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1"],"prefix":"10.1172","volume":"11","author":[{"given":"Wanrong","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine, JingGangShan University, Ji\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-You Wade","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, UCSD, La Jolla, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.337"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000748"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-00827-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0666-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.041"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180903125300"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091584"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055727"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316958"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3739"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03246-7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56346-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.90293.4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40982-z"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017751"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.757068"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031283"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/415219a"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.02.009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1404-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3791\/59588"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310230"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00800-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.001685"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab574"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.02.012"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.012"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw229"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad179"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00046"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-012-0109-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.043"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112385"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1021\/bi0489457"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23136937"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168463"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00434.2021"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15558"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.08.014"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/195761\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:02:27Z","timestamp":1787508147000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/195761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":40,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,7,16]]},"published-print":{"date-parts":[[2026,8,24]]}},"alternative-id":["10.1172\/jci.insight.195761"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.195761","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"article-number":"e195761"}}