{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:01:13Z","timestamp":1792130473723,"version":"4.4.0"},"reference-count":66,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"crossref","award":["R37 AI34495,R01 HL11879,P01 HL158505,P01 AI056299,R01 HL148164,P01 CA018029,R01 CA263090,R01 HL095791,P01 HL158504,U19 AI051731"],"award-info":[{"award-number":["R37 AI34495,R01 HL11879,P01 HL158505,P01 AI056299,R01 HL148164,P01 CA018029,R01 CA263090,R01 HL095791,P01 HL158504,U19 AI051731"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000885","name":"Children\u2019s Cancer Research Fund","doi-asserted-by":"crossref","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100000885","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:p>\n                    Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic transplantation. cGVHD pathophysiology involves cooperation between T follicular helper cells (TFHs) and germinal center B cells (GCBs), allo- and autoantibody depositions in cGVHD tissues, and fibrosis. We evaluated human CD19\u2013directed chimeric antigen receptor (CAR19) T cell therapy in a clinically relevant murine cGVHD model with bronchiolitis obliterans syndrome (BOS). Although CD8\n                    <jats:sup>+<\/jats:sup>\n                    CAR19 T cells effectively reduced peripheral B cell and GCB frequencies, pulmonary function was unimproved. In contrast, a single infusion of CAR19 CD4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (Tregs) mitigated ongoing pulmonary disease and modulated germinal centers (GCs) associated with reduced TFH frequencies compared with control Tregs but without measurable B cell depletion. Compared with EGFR Treg infusion, mice receiving CAR19 Tregs exhibited enhanced suppression of B cell activation and preserved splenic architecture, and CAR19 Treg infusion provided greater opportunities for interaction with CD19\n                    <jats:sup>+<\/jats:sup>\n                    B cells at the B cell follicle boundary zones. Taken together with the absence of detectable B cell cytolysis, these findings were most consistent with GC suppression rather than B cell depletion as the dominant mechanism. Overall, our findings suggest that CAR19 Tregs represent a promising and safe cGVHD\/BOS therapeutic strategy, offering immunosuppressive benefits and improved disease outcomes that may be more limited with CD8\n                    <jats:sup>+<\/jats:sup>\n                    CAR19 T cell treatment.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.196197","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:00:52Z","timestamp":1784044852000},"source":"Crossref","is-referenced-by-count":1,"title":["CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis"],"prefix":"10.1172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-3640","authenticated-orcid":true,"given":"Sujeong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, 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