{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:51:35Z","timestamp":1793407895515,"version":"4.5.0"},"reference-count":44,"publisher":"American Society for Clinical Investigation","issue":"23","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["R01AR079483"],"award-info":[{"award-number":["R01AR079483"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01RX002701"],"award-info":[{"award-number":["I01RX002701"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,8]]},"abstract":"<jats:p>Mammalian skin wounds typically heal with a scar, characterized by fibrotic tissue that disrupts original tissue architecture and function. Therapies that limit fibrosis and promote regenerative healing remain a major unmet clinical need. Rosemary extract, particularly in the form of topical oils and creams, has gained widespread public attention for its purported wound-healing properties. However, its efficacy and mechanism of action remain poorly understood. We show in adult wound healing mouse models that an ethanol-based rosemary extract accelerates the speed of wound healing and mitigates fibrosis. Mechanistically, we identify that carnosic acid, a major bioactive component of rosemary leaves, activates the transient receptor potential ankyrin 1 (TRPA1) nociceptor on cutaneous sensory neurons to enhance tissue regeneration. Mice lacking TRPA1 in sensory neurons do not exhibit these pro-regenerative responses, confirming its role as a critical mediator. Together, these findings suggest that topical rosemary extract may represent an effective and accessible therapeutic approach to improve skin repair outcomes.<\/jats:p>","DOI":"10.1172\/jci.insight.196267","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T19:36:36Z","timestamp":1761248196000},"source":"Crossref","is-referenced-by-count":4,"title":["Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation"],"prefix":"10.1172","volume":"10","author":[{"given":"Emmanuel","family":"Rapp","sequence":"first","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borna","family":"Saeednia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Marsh","family":"Prouty","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-0824","authenticated-orcid":true,"given":"Thomas H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Dermatology and"},{"name":"Corporal Michael J. 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