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Higher potassium (K\n                    <jats:sup>+<\/jats:sup>\n                    ) intake is positively correlated with bone health. Here, we investigated whether kidney calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) and phosphate (Pi) handling mechanisms mediate dietary K\n                    <jats:sup>+<\/jats:sup>\n                    effects. Kidney Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Pi handling proteins were altered in abundance in mice fed a 0% K\n                    <jats:sup>+<\/jats:sup>\n                    diet for 2 weeks. In mice fed a 0.1% K\n                    <jats:sup>+<\/jats:sup>\n                    diet for 4 or 8 weeks, urinary Ca\n                    <jats:sup>2+<\/jats:sup>\n                    excretion increased, plasma Ca\n                    <jats:sup>2+<\/jats:sup>\n                    levels were lower and plasma parathyroid hormone (PTH) levels were higher relative to control 1% K\n                    <jats:sup>+<\/jats:sup>\n                    fed mice. The 0.1% K\n                    <jats:sup>+<\/jats:sup>\n                    fed mice had greater excretion of the bone resorption marker deoxypyridinoline, increased osteoclast number, and decreased total femoral bone mineral density. During chronic low K\n                    <jats:sup>+<\/jats:sup>\n                    intake, major changes in renal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and Pi transport pathways were absent, except higher abundances of the sodium-potassium-chloride cotransporter (NKCC2) and the sodium-chloride cotransporter (NCC), in line with their role in kidney Ca\n                    <jats:sup>2+<\/jats:sup>\n                    handling. Low dietary K\n                    <jats:sup>+<\/jats:sup>\n                    induced hypocalcemia and changes in PTH were absent in mice with constitutively active NCC, supporting its role in mediating low K\n                    <jats:sup>+<\/jats:sup>\n                    effects on Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis. Our study provides insights into the management of bone disorders in conditions of chronic electrolyte imbalance.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.196339","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:00:26Z","timestamp":1769101226000},"source":"Crossref","is-referenced-by-count":2,"title":["Dietary potassium restriction causes hypercalciuria, hypocalcemia, and bone loss in male mice"],"prefix":"10.1172","volume":"11","author":[{"given":"Sathish K.","family":"Murali","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariavittoria","family":"D\u2019Acierno","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena K.","family":"Rosenbaek","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise N.","family":"Odgaard","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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