{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:49Z","timestamp":1787509309803,"version":"build-2736575974"},"reference-count":53,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["Overseas Research Fellowships"],"award-info":[{"award-number":["Overseas Research Fellowships"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P50DK096373,R01DK145876,R01DK116718,R01HL148044,P50DK133943,R01DK064324,R01DK123564"],"award-info":[{"award-number":["P50DK096373,R01DK145876,R01DK116718,R01HL148044,P50DK133943,R01DK064324,R01DK123564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:p>\n                    Renin cells are essential for survival and serve as key regulators of blood pressure and fluid-electrolyte homeostasis. Their function and identity are dependent on signals from their local microenvironment afforded by neighboring cells and nerves. Whether and how renin cells contribute to the development and maintenance of this microenvironment remains unclear. Because renin cells are rare \u2014 0.01 % of kidney cells \u2014 conventional histological approaches cannot capture their interaction with nerve fibers and surrounding cells within the nephron and its vasculature. Using high-resolution 3D imaging, cell-specific multicolor reporter mice, single-cell RNA-seq, and conditional gene deletions, we mapped how renin cells assemble within arterioles and communicate with axon fibers to organize the growth and orientation of the kidney arterioles during development and disease. This coinductive process is mediated by\n                    <jats:italic>Ngf<\/jats:italic>\n                    produced by renin cell precursors and is necessary for renin cell survival and innervation. Interestingly, renin enzymatic insufficiency elevates\n                    <jats:italic>Ngf<\/jats:italic>\n                    and drives arteriolar hypertrophy with aberrant axon sprouting and hyperinnervation. These findings indicate that renin cells regulate kidney neurovascular development, revealing them as active organizers of their local neuroregulatory microenvironment in health and disease.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.197709","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:18:51Z","timestamp":1784654331000},"source":"Crossref","is-referenced-by-count":0,"title":["Renin cells orchestrate a neuro-endocrine microenvironment of the kidney arterial tree in health and disease"],"prefix":"10.1172","volume":"11","author":[{"given":"Manako","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gyarmati","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience and Department of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Ferreira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3169-014X","authenticated-orcid":true,"given":"Alexandre G.","family":"Martini","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Faculty of Health Sciences, University of Bras\u00edlia, Bras\u00edlia, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Wilmsen","sequence":"additional","affiliation":[{"name":"Molecular Electron Microscopy Core and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Hao","sequence":"additional","affiliation":[{"name":"Advanced Microscopy Facility, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tainaka","sequence":"additional","affiliation":[{"name":"Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University, Niigata, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-2800","authenticated-orcid":true,"given":"Silvia","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA."},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-6185","authenticated-orcid":true,"given":"Janos","family":"Peti-Peterdi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience and Department of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-7940","authenticated-orcid":true,"given":"Maria Luisa S.","family":"Sequeira-Lopez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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