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VIRMA is the largest core subunit of the m\n                    <jats:sup>6<\/jats:sup>\n                    A methyltransferase complex and is essential for the assembly and stability of the m\n                    <jats:sup>6<\/jats:sup>\n                    A methyltransferase complex. In the retina, m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation modification is widely distributed in various cellular layers and is essential for retinal homeostasis. Here, we demonstrate that VIRMA-mediated m6A modification is essential for retinal homeostasis. Loss of\n                    <jats:italic>Virma<\/jats:italic>\n                    in retinal rod cells resulted in abnormal reduction in m\n                    <jats:sup>6<\/jats:sup>\n                    A methylation levels, along with impaired photoreceptor function and degeneration. Mechanically,\n                    <jats:italic>Virma<\/jats:italic>\n                    depletion in photoreceptors dampened the m\n                    <jats:sup>6<\/jats:sup>\n                    A modification level of visual perception\u2013associated genes, resulting compromised visual function and photoreceptors degeneration. Moreover,\n                    <jats:italic>Virma<\/jats:italic>\n                    interacted with splicing factor to regulate the alternative splicing events of retina function\u2013related genes such as\n                    <jats:italic>Polg2<\/jats:italic>\n                    , which contributes to photoreceptor damage. Reintroduction of normal\n                    <jats:italic>Virma<\/jats:italic>\n                    expression colonially rescued photoreceptor degeneration. Collectively, our data elucidate the important role of\n                    <jats:italic>Virma<\/jats:italic>\n                    -mediated m\n                    <jats:sup>6<\/jats:sup>\n                    A modification in photoreceptor function and suggest that epigenetic modulation could serve as a potential target to treat these blinding diseases.\n                  <\/jats:p>\n                  <jats:p>Restoring epigenetic regulator Virma prevents photoreceptor cell death in the retina, rescuing vision and offering a new strategy against blindness.<\/jats:p>","DOI":"10.1172\/jci.insight.197880","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:18:08Z","timestamp":1774016288000},"source":"Crossref","is-referenced-by-count":0,"title":["VIRMA modulates function of photoreceptor cells through m6A modification and alternative splicing"],"prefix":"10.1172","volume":"11","author":[{"given":"Wenjing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics and"},{"name":"The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Center for Medical Genetics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zou","sequence":"additional","affiliation":[{"name":"The Sichuan Provincial Key Laboratory for Human Disease Gene Study and Center for Medical Genetics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Chinagene Co. 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