{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:09:41Z","timestamp":1778875781280,"version":"3.51.4"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01-AI259057,R21-AI157864,UM1 AI126619"],"award-info":[{"award-number":["R01-AI259057,R21-AI157864,UM1 AI126619"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["P30AI117970"],"award-info":[{"award-number":["P30AI117970"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["UM1 AI126619"],"award-info":[{"award-number":["UM1 AI126619"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,23]]},"abstract":"<jats:p>\n                    Latently infected cells persist in people living with HIV (PWH) despite suppressive antiretroviral therapy (ART) and evade immune clearance. \u201cShock and Kill\u201d cure strategies are hampered by insufficient enhancement of targeted immune responses following latency reversal. We previously demonstrated that autologous V\u03b42 T cells from PWH retain anti-HIV activity and can reduce CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell reservoirs, although their use in cure approaches is limited due to their dual role as a viral reservoir. However, promising clinical data in oncology shows that their unique MHC-unrestricted antigen recognition affords potent on-target cytotoxicity in the absence of graft-versus-host disease when used as an allogeneic adoptive cell therapy modality. Here, we found expanded allogeneic V\u03b42 T cells specifically eliminated HIV-infected CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and monocyte-derived macrophages (MDM), overcoming inherent resistance to killing by other cell types such as NK and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Notably, we demonstrated that allogeneic V\u03b42 T cells recognized and eliminated the HIV-latent CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell reservoir following latency reversal. Our study provides evidence for developing an allogeneic \u03b3\u03b4 T cell therapy for HIV cure and warrants preclinical investigation in combination approaches.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.198185","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:00:44Z","timestamp":1770742844000},"source":"Crossref","is-referenced-by-count":0,"title":["Ex vivo\u2013expanded allogeneic V\u03b42 T cells specifically reduce reservoirs of HIV-1 following latency reversal"],"prefix":"10.1172","volume":"11","author":[{"given":"Brendan T.","family":"Mann","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Tropical Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Tropical Medicine, 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