{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:12:16Z","timestamp":1780085536566,"version":"3.54.0"},"reference-count":84,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministry of Health","award":["PHRC COVID-19\u201320\u20130151,PHRC COVID-19\u201320\u20130029"],"award-info":[{"award-number":["PHRC COVID-19\u201320\u20130151,PHRC COVID-19\u201320\u20130029"]}]},{"name":"Fondation de l\u2019Assistance Publique \u2212 H\u00f4pitaux de Paris","award":["Alliance Tous Unis Contre le Virus"],"award-info":[{"award-number":["Alliance Tous Unis Contre le Virus"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["REA202010012514,MONICOR"],"award-info":[{"award-number":["REA202010012514,MONICOR"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agence Nationale de Recherches sur le Sida and emerging infectious diseases - ANRS","award":["ANRS0147 from the VINTED sponsorship"],"award-info":[{"award-number":["ANRS0147 from the VINTED sponsorship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>After identifying 2 immunomarkers of acute injury, KIM-1 and LCN2, in all kidney biopsies from 31 patients with COVID-19 pneumonia and de novo kidney dysfunction, we investigated whether circulating markers of kidney epithelial injury are common in patients with laboratory-confirmed COVID-19 who require oxygen support but do not have critical illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We studied 196 patients admitted to 15 hospitals with moderate to severe pneumonia who were enrolled in 2 independent randomized clinical trials. We measured 41 immune mediators and markers of kidney and endothelial injury in peripheral blood in these patients within 24 hours of randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We constructed a generalized linear CORIMUNO model combining serum levels of KIM-1, LCN2, IL-10, and age at hospital admission that showed high discrimination for mortality (derivation cohort: AUC = 0.82, 95% CI: 0.73\u20130.92; validation cohort: AUC = 0.83, 95% CI: 0.74\u20130.92). An early rise in circulating kidney injury markers, in the absence of acute kidney injury criteria, was markedly associated with the risk of developing a severe form of COVID-19 and death within 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The CORIMUNO score may be a helpful tool for risk stratification, and for the first time to our knowledge, it identifies the overlooked impact of subclinical kidney injury on pneumonia outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT04324047, NCT04324073, and NCT04331808.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>This research was funded by the French Ministry of Health, Programme Hospitalier de Recherche Clinique (PHRC COVID-19\u201320\u20130151, PHRC COVID-19\u201320\u20130029), Fondation de l\u2019Assistance Publique H\u00f4pitaux de Paris (Alliance Tous Unis Contre le Virus), Assistance Publique H\u00f4pitaux de Paris, and grants from the Fondation pour la Recherche M\u00e9dicale (FRM) (REA202010012514) and Agence Nationale de Recherches sur le Sida and emerging infectious diseases (ANRS) (ANRS0147) from the VINTED sponsorship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.198244","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:00:43Z","timestamp":1769108443000},"source":"Crossref","is-referenced-by-count":1,"title":["Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death"],"prefix":"10.1172","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-6987","authenticated-orcid":true,"given":"Olivia","family":"Lenoir","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, Paris Cardiovascular research Center (PARCC), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Morin","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie et d\u2019Histocompatibilit\u00e9, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Walter-Petrich","sequence":"additional","affiliation":[{"name":"Biostatistics and Medical Information Department, Saint-Louis Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Resmini","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, Paris Cardiovascular research Center (PARCC), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Zaidan","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation, Bic\u00eatre Hospital, Assistance Publique H\u00f4pitaux de Paris, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France."},{"name":"Center for Rare Diseases, \u201cIdiopathic Nephrotic Syndrome,\u201d Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Mahtal","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, Paris Cardiovascular research Center (PARCC), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Ferlicot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bic\u00eatre Hospital, Assistance Publique H\u00f4pitaux de Paris, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-5462","authenticated-orcid":true,"given":"Victor G.","family":"Puelles","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, and"},{"name":"Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-7020","authenticated-orcid":true,"given":"Nicola","family":"Wanner","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, and"},{"name":"Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dang","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, Paris Cardiovascular research Center (PARCC), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-5836","authenticated-orcid":true,"given":"Thibaut","family":"d\u2019Izarny-Gargas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM, Paris Cardiovascular research Center (PARCC), Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Biermann","sequence":"additional","affiliation":[{"name":"Program for Mathematical Genomics, Columbia University, New York, New York, USA."},{"name":"Department of Medicine, Division of 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