{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:26:45Z","timestamp":1788402405141,"version":"build-2803163510"},"reference-count":104,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n","award":["FONDECYT 1190144,FONDECYT 1230054"],"award-info":[{"award-number":["FONDECYT 1190144,FONDECYT 1230054"]}]},{"name":"Centro de Envejecimiento y Regeneraci\u00f3n","award":["CARE-AFB170005"],"award-info":[{"award-number":["CARE-AFB170005"]}]},{"name":"Centro Cient\u00edfico y Tecnol\u00f3gico de Excelencia Ciencia & Vida","award":["FC&V Basal FB210008"],"award-info":[{"award-number":["FC&V Basal FB210008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,22]]},"abstract":"<jats:p>\n                    Lysophosphatidic acid (LPA) is a bioactive lipid that signals through G protein\u2013coupled receptors (LPA\n                    <jats:sub>1\u20136<\/jats:sub>\n                    ) and regulates multiple cellular processes, including fibrosis. Although LPA signaling has been implicated in fibrotic diseases in several organs, its role in skeletal muscle remains unclear. Here, we show that LPA\/LPA\n                    <jats:sub>1<\/jats:sub>\n                    signaling promotes fibrogenesis after sciatic nerve transection. Denervation induces differential expression of LPA signaling axis components and a transient early increase in intramuscular LPA levels. Pharmacological inhibition of LPA\n                    <jats:sub>1\/3<\/jats:sub>\n                    with Ki16425, or genetic deletion of LPA\n                    <jats:sub>1<\/jats:sub>\n                    , reduces extracellular matrix accumulation and expansion of fibro\/adipogenic progenitors (FAPs) in denervated muscle. Although LPA blockade suppresses atrophy-related gene expression, it does not fully preserve myofiber size. Mechanistically, denervation increases YAP\/TAZ expression, nuclear localization in FAPs, and transcriptional activity, effects that are attenuated by LPA axis inhibition. Furthermore, pharmacological inhibition of YAP\/TAZ with verteporfin reduces fibrosis after denervation, supporting their role as critical downstream mediators. Finally, transient denervation activates the LPA axis, promotes muscle fibrosis, reduces axonal density in the sciatic nerve, and increases neuromuscular junction instability, effects reversed by Ki16425. Together, these findings identify the LPA\/LPA\n                    <jats:sub>1<\/jats:sub>\n                    \/YAP\/TAZ pathway as a key driver of denervation-induced muscle fibrosis and a potential therapeutic target in neuromuscular disorders.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.198388","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:00:45Z","timestamp":1776794445000},"source":"Crossref","is-referenced-by-count":2,"title":["Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP\/TAZ"],"prefix":"10.1172","volume":"11","author":[{"given":"Meilyn","family":"Cruz-Soca","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad San Sebasti\u00e1n, Providencia, Chile."},{"name":"Centro Cient\u00edfico y Tecnol\u00f3gico de Excelencia Ciencia & Vida, Huechuraba, 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