{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:16:14Z","timestamp":1791598574423,"version":"4.3.4"},"reference-count":87,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":45,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health (NIH) ; National Cancer Institute","award":["P51 OD011104,R01 AI167644,"],"award-info":[{"award-number":["P51 OD011104,R01 AI167644,"]}]},{"name":"National Institute of Health (NIH) ; National Cancer Institute","award":["R21 OD031229,S10 OD026800,OD011104,75N91019D00024"],"award-info":[{"award-number":["R21 OD031229,S10 OD026800,OD011104,75N91019D00024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:p>\n                    Cytomegalovirus (CMV) is a prevalent \u03b2-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with HIV-1 persistence and particular inflammatory-related comorbidities. The true causative role of CMV in HIV-associated pathologies, however, remains unclear given that nearly all PWH are coinfected with CMV. In this study, we examined acute phase immune and virological dynamics in cohorts of SIV-infected rhesus macaques (RMs) that were naturally seropositive or -negative for rhesus CMV (RhCMV). We observed prior to SIV, RhCMV expanded a polyclonal population of target CCR5\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in gut and lymph nodes that expressed the chemotactic receptor CXCR3 and were largely not specific for RhCMV. Upon SIV infection, RhCMV\n                    <jats:sup>+<\/jats:sup>\n                    RMs exhibited higher peak viremia and elevated levels of SIV DNA in the upper and lower intestine. Greater seeding of SIV DNA was associated with a maintenance of CCR5-expressing CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that were enriched within the RhCMV\n                    <jats:sup>+<\/jats:sup>\n                    gut along a CXCR3\/CXCL9 chemotactic axis. Overall, the data suggest that RhCMV can promote SIV susceptibility within a diverse, polyclonal pool of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that are not entirely RhCMV specific.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.198743","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:00:56Z","timestamp":1764090056000},"source":"Crossref","is-referenced-by-count":2,"title":["RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa"],"prefix":"10.1172","volume":"11","author":[{"given":"Chrysostomos","family":"Perdios","sequence":"first","affiliation":[{"name":"Division of Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Suresh Babu","sequence":"additional","affiliation":[{"name":"Division of Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste 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