{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:45Z","timestamp":1787509305489,"version":"build-2736575974"},"reference-count":57,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIDDK","award":["R03 DK 131156"],"award-info":[{"award-number":["R03 DK 131156"]}]},{"name":"NIH\/NIDDK","award":["K23DK118190"],"award-info":[{"award-number":["K23DK118190"]}]},{"name":"NIH\/NIDDK","award":["NIH P30DK116074"],"award-info":[{"award-number":["NIH P30DK116074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Elucidating immune signals through well-defined cohorts of pediatric acute pancreatitis (AP) and chronic pancreatitis (CP) patients is critical. This study aimed to evaluate plasma chemokine and cytokine levels in pediatric participants with CP, compared with AP and healthy controls (HCs), to identify unique biomarkers of CP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Individuals were identified from a prospectively collected pediatric cohort (\n                      <jats:italic>n<\/jats:italic>\n                      = 146). Immunoproteins (\n                      <jats:italic>n<\/jats:italic>\n                      = 247) were measured using the NULISAseq platform on samples from individuals with CP (\n                      <jats:italic>n<\/jats:italic>\n                      = 71), AP (\n                      <jats:italic>n<\/jats:italic>\n                      = 55), and HCs (\n                      <jats:italic>n<\/jats:italic>\n                      = 20).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The measured analytes showed separation among the 3 groups (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.13,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). In the CP group, TRANCE, TWEAK, FLT-1, HGF, and TRAIL were increased when compared with HC and AP patients (FDR-corrected\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). A multivariable logistic regression model including all 5 proteins provided an AUC of 0.94 (0.93\u20130.96) for differentiating samples from CP versus AP or HC samples. In the AP group, CRP, IL-6, CD3E, ENRAGE, and MIF were elevated compared with HCs, while FGF-2, TAFA-5, IL-33, TRANCE, and CXCL12 were downregulated in the same acute time period (FDR-corrected\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). In the 21 patients with AP for whom follow-up samples were obtained, there was a notable decrease in sequential expression of IL-6 and CRP over 12 months and increased expression of CCL25, TAFA-5, and TRANCE proteins. Additionally, TRANCE was expressed on CP pancreatic tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>TRANCE was increased in pediatric patients with CP and decreased in those with AP during a flare. Future studies are needed to investigate the role of TRANCE and other analytes in the pathogenesis of CP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.198911","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:01:06Z","timestamp":1787508066000},"source":"Crossref","is-referenced-by-count":0,"title":["TRANCE is a unique marker of chronic pancreatitis in children"],"prefix":"10.1172","volume":"11","author":[{"given":"Peter R.","family":"Farrell","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children\u2019s Hospital Medical Cincinnati, Ohio, USA."},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology, and 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