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In mice, T cells have been shown to be imperative in disease progression and lethality, whereas in humans, an early and robust T cell response has been associated with survival. Here, we assessed the role of CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells on disease progression and severity of Lassa virus infection in a nonhuman primate model. Using an antibody-mediated T cell depletion strategy prior to and after inoculation, we were able to examine Lassa virus infection in the absence of specific T cell responses. In animals depleted for either CD4\n                    <jats:sup>+<\/jats:sup>\n                    or CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, Lassa virus infection remained uniformly lethal, with only a slight delay in disease progression was observed in the CD4-depleted group when compared with nondepleted controls. Milder pulmonary pathology was noticed in the absence of CD4\n                    <jats:sup>+<\/jats:sup>\n                    or CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Overall, our findings suggest that T cells have a limited effect on the development of Lassa fever in nonhuman primates.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.199235","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:00:49Z","timestamp":1758816049000},"source":"Crossref","is-referenced-by-count":2,"title":["CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques"],"prefix":"10.1172","volume":"10","author":[{"given":"J\u00e9r\u00e9mie","family":"Pr\u00e9vost","sequence":"first","affiliation":[{"name":"Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikesh","family":"Tailor","sequence":"additional","affiliation":[{"name":"Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba 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