{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:08:35Z","timestamp":1778875715725,"version":"3.51.4"},"reference-count":47,"publisher":"American Society for Clinical Investigation","issue":"7","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,8]]},"abstract":"<jats:p>\n                    The contribution of 9p deletion to B cell acute lymphoblastic leukemia (B-ALL) has remained elusive since its discovery more than 40 years ago. Here we show that loss of\n                    <jats:italic>CD72<\/jats:italic>\n                    is recurrent in B-ALL cases containing\n                    <jats:italic>PAX5<\/jats:italic>\n                    deletions, and that\n                    <jats:italic>Cd72<\/jats:italic>\n                    haploinsufficiency drives B-ALL development in\n                    <jats:italic>\n                      Pax5\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Mechanistically,\n                    <jats:italic>\n                      Cd72\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    ;\n                    <jats:italic>\n                      Pax5\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    precursor B cells exhibited an inflammatory transcriptional profile characterized by a decrease in\n                    <jats:italic>Myd88<\/jats:italic>\n                    expression, a finding that aligns with our previous studies of B-ALL development in\n                    <jats:italic>\n                      Pax5\n                      <jats:sup>+\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice following exposure to immune stressors. These combined genomic analyses and functional models provide compelling evidence that co-deletion of 2 contiguous genes,\n                    <jats:italic>Pax5<\/jats:italic>\n                    and\n                    <jats:italic>Cd72<\/jats:italic>\n                    , drives B cell leukemogenesis.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.199464","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:00:11Z","timestamp":1771347611000},"source":"Crossref","is-referenced-by-count":0,"title":["Deletion of 9p drives B-ALL through heterozygous inactivation of Pax5 and Cd72 in preleukemic cells"],"prefix":"10.1172","volume":"11","author":[{"given":"Bel\u00e9n","family":"Ruiz-Corzo","sequence":"first","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, Salamanca, Spain."},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Casado-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, Salamanca, Spain."},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninad","family":"Oak","sequence":"additional","affiliation":[{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Somoza-Cotillas","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, Salamanca, Spain."},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lo\u0301pez-A\u0301lvarez de Neyra","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, Salamanca, Spain."},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Mart\u00ednez-Cano","sequence":"additional","affiliation":[{"name":"Immune system development and function Unit, Centro de Biolog\u00eda Molecular Severo Ochoa (Consejo Superior de Investigaciones Cient\u00edficas -Universidad Aut\u00f3noma de Madrid), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"P\u00e9rez-Pons","sequence":"additional","affiliation":[{"name":"Cancer Research Center (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), University of Salamanca, Salamanca, Spain, and Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain."},{"name":"Biomedical Research Networking Center Consortium (CIBERONC; CB16\/12\/00400), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena G.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Oncohematology Laboratory, Advance Terapy Unit, Fundaci\u00f3n para la Investigaci\u00f3n Biom\u00e9dica del Hospital Universitario Ni\u00f1o Jes\u00fas (FIB HUNJ), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Blanco","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Universidad de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Alonso-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"De Las Rivas","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Bioinformatics and Functional Genomics Research Group, Cancer Research Center (CSIC-USAL), Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Riesco","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Department of Pediatrics, Hospital Universitario de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Prieto-Matos","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Department of Pediatrics, Hospital Universitario de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Garc\u00eda Criado","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Departamento de Cirug\u00eda, Universidad de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Bego\u00f1a","family":"Garc\u00eda Cenador","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Departamento de Cirug\u00eda, Universidad de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[{"name":"Cancer Research Center (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), University of Salamanca, Salamanca, Spain, and Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain."},{"name":"Biomedical Research Networking Center Consortium (CIBERONC; CB16\/12\/00400), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-6973","authenticated-orcid":true,"given":"Manuel","family":"Ram\u00edrez-Orellana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas and Institute of Biomedical Research Hospital Universitario La Princesa, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Cobaleda","sequence":"additional","affiliation":[{"name":"Immune system development and function Unit, Centro de Biolog\u00eda Molecular Severo Ochoa (Consejo Superior de Investigaciones Cient\u00edficas -Universidad Aut\u00f3noma de Madrid), Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Vicente-Due\u00f1as","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."},{"name":"Department of Pediatrics, Hospital Universitario de Salamanca, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-6555","authenticated-orcid":true,"given":"Kim E.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, Salamanca, Spain."},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Universidad de Salamanca, Campus Miguel de Unamuno s\/n, Salamanca, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.3.735.735"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508013130503"},{"issue":"5","key":"B3","first-page":"1537","article-title":"Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: a report from the Children\u2019s Cancer Group","volume":"94","author":"Heerema","year":"1999","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90086-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.409.409"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13227"},{"issue":"7","key":"B7","first-page":"541","article-title":"Abnormalities of the short arm of chromosome 9 with partial loss of material in hematological disorders","volume":"1","author":"Pollak","year":"1987","journal-title":"Leukemia"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70339-5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2011.04.003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166801"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.01.014"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0892"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004381"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13570-y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.08.002"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-1091"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00505-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40961-z"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76206-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16523"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36428"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.02.006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nature25795"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01159-z"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1462-1470.2006"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90079-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80124-7"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.120.303596"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-02014-7"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp698"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2514"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr665"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1029-6"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0051-x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004873"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts378"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-6-r84"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv710"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1101\/gr.222109.117"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14061"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3505"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3262"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/199464\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:17:21Z","timestamp":1778872641000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/199464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,2,19]]},"published-print":{"date-parts":[[2026,4,8]]}},"alternative-id":["10.1172\/jci.insight.199464"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.199464","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"article-number":"e199464"}}