{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:16:04Z","timestamp":1779387364957,"version":"3.53.1"},"reference-count":79,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["DK134431"],"award-info":[{"award-number":["DK134431"]}]},{"name":"NIH","award":["DK119183"],"award-info":[{"award-number":["DK119183"]}]},{"name":"NIH","award":["DK138907"],"award-info":[{"award-number":["DK138907"]}]},{"name":"NIH","award":["1S10OD028596"],"award-info":[{"award-number":["1S10OD028596"]}]},{"name":"NIH","award":["U54 DK137329"],"award-info":[{"award-number":["U54 DK137329"]}]},{"name":"AUA","award":["Urology Care Foundation Research Scholar Award Program"],"award-info":[{"award-number":["Urology Care Foundation Research Scholar Award Program"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,22]]},"abstract":"<jats:p>\n                    Small-conductance Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -activated K\n                    <jats:sup>+<\/jats:sup>\n                    (SK) channels regulate neuronal excitability and act as a feedback mechanism to limit firing during sustained stimulation. In the present study, we demonstrated that SK2 plays an important role in the control of bladder function and visceral pain processing. SK2 channels are expressed in bladder-innervating afferent neurons, and ablation of this subunit results in elevated afferent firing rates in response to physiological levels of bladder distension, supporting a role for SK2 in modulating mechanosensory excitability. Mice overexpressing SK2 exhibit increased bladder capacity and reduced voiding frequency. Furthermore, overexpression of SK2 prevents the onset of pelvic mechanical allodynia and attenuates the exaggerated visceromotor response to bladder distension seen in wild-type mice with chemical cystitis. 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