{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:52:24Z","timestamp":1792799544649,"version":"4.5.0"},"reference-count":39,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European joint programme for rare diseases","award":["OptiMyG,grant no. 2023-00533"],"award-info":[{"award-number":["OptiMyG,grant no. 2023-00533"]}]},{"name":"Region Stockholm","award":["FoUI-987565"],"award-info":[{"award-number":["FoUI-987565"]}],"id":[{"id":"https:\/\/ror.org\/02zrae794","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2023-00533"],"award-info":[{"award-number":["2023-00533"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kogod Centre on Aging, Medical Research Council","award":["MR\/V007173\/1"],"award-info":[{"award-number":["MR\/V007173\/1"]}],"id":[{"id":"https:\/\/ror.org\/011y3zn24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wellcome Trust Fellowship","award":["104079\/Z\/14\/Z"],"award-info":[{"award-number":["104079\/Z\/14\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:p>\n                    The 2 main subgroups of autoimmune myasthenia gravis, a neuromuscular junction disorder associated with muscle weakness, are early- and late-onset forms, defined by onset before or after 50 years of age. Both carry acetylcholine-receptor autoantibodies but differ in sex ratios, genetics, and occurrence of disease-specific thymus inflammation. To distinguish the 2 forms by cellular immune phenotyping, we applied multimodal techniques, including deep spectral cytometric phenotyping and single-cell sequencing. Analysis of 2 independent cohorts identified immunological differences driven by 3 main lymphocyte populations. Lower frequencies of mucosa-associated invariant T cells and naive CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were observed in late-onset myasthenia, suggesting enhanced immune senescence. A highly differentiated, canonical NK cell population was reduced in early-onset myasthenia and negatively correlated with the degree of thymic hyperplasia. Using only the frequency of these 3 populations, correct myasthenia subgroup assignment could be predicted with 90% accuracy. These distinct immunocellular endophenotypes for early- and late-onset disease suggest differences in immunopathogenic processes. Along with demographic factors and other disease subgroup\u2013specific features, the frequency of the identified cell subpopulations may improve clinical classification.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.199679","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:00:26Z","timestamp":1764262826000},"source":"Crossref","is-referenced-by-count":6,"title":["Cellular immune endophenotypes separating early and late-onset myasthenia gravis"],"prefix":"10.1172","volume":"11","author":[{"given":"Jakob","family":"Theorell","sequence":"first","affiliation":[{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Neurology, Karolinska University Hospital, Stockholm, 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