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However, their role in pulmonary fibrosis (PF) remains unclear. Here, we identified a previously unrecognized population of lung capillary EPCs coexpressing c-KIT and FOXF1 (capEPCs) in adult human and mouse lungs. capEPCs were significantly reduced in lungs from patients with PF and in bleomycin-injured mice, implicating loss of this regenerative endothelial population in disease pathogenesis. Transplantation of donor capEPCs attenuated experimental PF, improved survival, reduced collagen deposition, and restored lung function. Donor capEPCs engrafted into the lung microcirculation of bleomycin-injured mice. Single-cell RNA sequencing identified interferon-induced transmembrane protein 3 as a highly enriched transcript in capEPCs. Conditioned media from IFITM3-overexpressing EPCs or recombinant IFITM3 enhanced endothelial proliferation and angiogenesis while suppressing TGF-\u03b21\u2013induced fibroblast activation in vitro. IFITM3 was found in capEPC-derived exosomes. Treatment with IFITM3-containing exosomes recapitulated the therapeutic effects of capEPC transplantation by improving endothelial function, inhibiting fibroblast activation, increasing animal survival, reducing lung fibrosis, and restoring lung function. Together these findings identified capEPC deficiency as a feature of PF and demonstrated that IFITM3-containing exosomes promoted vascular repair. Restoration of capEPC regenerative function or delivery of IFITM3-enriched exosomes may represent a promising therapeutic strategy for human PF.<\/jats:p>","DOI":"10.1172\/jci.insight.199743","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:00:57Z","timestamp":1791396057000},"source":"Crossref","is-referenced-by-count":0,"title":["Transplantation of endothelial progenitor cells attenuates pulmonary fibrosis via IFITM3-containing exosomes"],"prefix":"10.1172","volume":"11","author":[{"family":"Lan","sequence":"first","affiliation":[{"name":"Phoenix Children\u2019s Research Institute, Department of Child Health, University of Arizona College of Medicine\u2013Phoenix, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Do","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Research Institute, Department of Child Health, University of Arizona College of 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