{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:45:17Z","timestamp":1786466717458,"version":"build-2736575974"},"reference-count":89,"publisher":"American Society for Clinical Investigation","issue":"15","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI155678"],"award-info":[{"award-number":["R01AI155678"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32GM007863"],"award-info":[{"award-number":["T32GM007863"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:p>\n                    B cells contribute to the pathogenesis of food allergies as they induce allergen-specific antibody production. Clinically used allergen-specific immunotherapies have been shown to induce regulatory B cell subsets as well as target and reduce allergy-driving B cell functions. This report aims to elucidate the contribution of regulatory B cells to an allergen-encapsulating nanoparticle (aeNP) immunotherapy in a murine model of food allergy. In this model, B cells directly associated with aeNPs. CD20\n                    <jats:sup>+<\/jats:sup>\n                    B cell depletion after aeNP treatment increased the number of mice with severe allergic reactions during oral food challenges and reduced the expansion of regulatory immune cells including CD103\n                    <jats:sup>+<\/jats:sup>\n                    DCs and CCR9\n                    <jats:sup>+<\/jats:sup>\n                    gut-homing Tregs, indicating that B cells are a component of aeNP immunomodulation. B cell communication in the gastrointestinal tract of aeNP-treated mice identified CD23 signaling as a potential inducer of regulatory CD103\n                    <jats:sup>+<\/jats:sup>\n                    DC functions and disrupter of allergy-driving B cell\u2013T cell communication. These tolerogenic signaling patterns were also identified in IL-10\n                    <jats:sup>+<\/jats:sup>\n                    B cells, which are known to impart regulatory immune effects in both murine and human disease. Ultimately, B cells are a component of the complex immunomodulation leading to aeNP efficacy at reducing allergic reactivity.\n                  <\/jats:p>\n                  <jats:p>An effective preclinical allergen-specific nanoparticle immunotherapy for food allergies induces a multifaceted immune modulation, with contributions from a subset of regulatory B cells.<\/jats:p>","DOI":"10.1172\/jci.insight.199988","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:00:42Z","timestamp":1781020842000},"source":"Crossref","is-referenced-by-count":1,"title":["Regulatory B cells contribute to allergen-encapsulating nanoparticle immunotherapy efficacy for food allergy"],"prefix":"10.1172","volume":"11","author":[{"given":"Laila M.","family":"Rad","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna W.","family":"Janczak","sequence":"additional","affiliation":[{"name":"Mary H. 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