{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:42:41Z","timestamp":1792464161501,"version":"4.5.0"},"reference-count":62,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Breakthrough T1D","award":["2-SRA-2022-1220-S-B"],"award-info":[{"award-number":["2-SRA-2022-1220-S-B"]}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01AI142428"],"award-info":[{"award-number":["R01AI142428"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Breakthrough T1D","award":["3-SRA-2023-1295-S-B,3-SRA-2024-1555-S-B,2-SRA-2023-1314-S-B"],"award-info":[{"award-number":["3-SRA-2023-1295-S-B,3-SRA-2024-1555-S-B,2-SRA-2023-1314-S-B"]}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"crossref","award":["1-25-PDF-01"],"award-info":[{"award-number":["1-25-PDF-01"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["U01DK123559,R01DK127778,P30DK026687,U01DK123594,UC4DK112232,U01DK123716,T32DK007120,R01DK114233,R01DK127497,R01DK138469,UG3DK142188,P30DK063608"],"award-info":[{"award-number":["U01DK123559,R01DK127778,P30DK026687,U01DK123594,UC4DK112232,U01DK123716,T32DK007120,R01DK114233,R01DK127497,R01DK138469,UG3DK142188,P30DK063608"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["P30CA013696"],"award-info":[{"award-number":["P30CA013696"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:p>\n                    Stem cell\u2013derived \u03b2 cells offer a promising approach for type 1 diabetes (T1D) treatment. However, the processes of graft infiltration and rejection by immune cells remain poorly understood in humans. In this study, autologous or allogeneic stem cell\u2013derived islets (SC-islets) were transplanted in human immune system mice and analyzed 14 to 18 weeks later. Imaging mass cytometry revealed unique characteristics of SC-islet grafts, including a high percentage of glucagon\n                    <jats:sup>+<\/jats:sup>\n                    cells and the presence of cysts and CD57\n                    <jats:sup>+<\/jats:sup>\n                    enterochromaffin cells, features not typically observed in endogenous or transplanted allogeneic primary pancreatic islets. Allogeneic SC-islet grafts exhibited heavy immune infiltration, cell proliferation, and pro-fibrotic processes, whereas autologous grafts showed minimal infiltration and little fibrosis. In some mice, autologous T cells expressing islet antigen-reactive (IAR) T cell receptors (TCRs) were adoptively transferred. Three weeks after transfer, autologous grafts injected with IAR-TCR\n                    <jats:sup>+<\/jats:sup>\n                    T cells showed negligible immune infiltration, even though IAR-TCR\n                    <jats:sup>+<\/jats:sup>\n                    T cells were detected in the spleen. Under the conditions tested, human SC-islet grafts were not rejected by an autologous immune system, even in the presence of autoreactive T cells, pointing to several limitations that remain to be addressed for a model of spontaneous autologous SC-islet infiltration and destruction.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.200738","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:54:14Z","timestamp":1780937654000},"source":"Crossref","is-referenced-by-count":2,"title":["Modeling immune responses to autologous and allogeneic human stem cell\u2013derived islet grafts in vivo"],"prefix":"10.1172","volume":"11","author":[{"given":"Camillo","family":"Bechi Genzano","sequence":"first","affiliation":[{"name":"Columbia Center for Translational Immunology and Department of Medicine,"},{"name":"Naomi Berrie Diabetes Center, 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