{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:41Z","timestamp":1787509301864,"version":"build-2736575974"},"reference-count":29,"publisher":"American Society for Clinical Investigation","issue":"16","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["[82102338]"],"award-info":[{"award-number":["[82102338]"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"he Joint Construction Project of Henan Medical Science and Technology Research Program","award":["LHGJ20230449"],"award-info":[{"award-number":["LHGJ20230449"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,24]]},"abstract":"<jats:p>\n                    Chronic, non-healing wounds are a severe diabetic complication. The underlying mechanisms are not fully understood, and the role of ATF7 in this context has not been well characterized. In our study, we utilized db\/db diabetic mice and AAV-mediated keratinocyte-specific\n                    <jats:italic>Atf7<\/jats:italic>\n                    overexpression in vivo. HaCaT keratinocyte\/THP-1 macrophage cocultures under high glucose were used in vitro. Our results showed that ATF7 was upregulated in diabetic wounds. Keratinocyte-specific\n                    <jats:italic>Atf7<\/jats:italic>\n                    overexpression accelerated diabetic wound closure, enhanced re-epithelialization, granulation tissue formation, and keratinocyte proliferation, while suppressing macrophage M1 polarization and inflammation. Multiomics screening identified NOTCH1 as a key ATF7 target. ATF7 transcriptionally repressed NOTCH1 by recruiting Suv39h1, increasing H3K9me3 at the\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    promoter. This reduced NOTCH1 protein and its active intracellular domain (N1ICD) within keratinocyte-derived exosomes.\n                    <jats:italic>ATF7<\/jats:italic>\n                    -overexpressing keratinocyte exosomes carried less N1ICD, leading to decreased N1ICD transfer to macrophages and subsequent inhibition of M1 polarization. Notably, local injection of exosomes from\n                    <jats:italic>ATF7<\/jats:italic>\n                    -overexpressing keratinocytes accelerated wound healing in db\/db mice. In summary, ATF7 promotes diabetic wound healing by repressing NOTCH1 transcription via H3K9me3, thereby reducing exosomal N1ICD secretion from keratinocytes and inhibiting macrophage M1 polarization. This identifies the ATF7\/NOTCH1\/exosome axis as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.201178","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:01:06Z","timestamp":1787508066000},"source":"Crossref","is-referenced-by-count":0,"title":["ATF7 drives diabetic wound healing via NOTCH1 repression and N1ICD-dependent macrophage polarization control"],"prefix":"10.1172","volume":"11","author":[{"given":"Pengcheng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Head and Neck Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 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