{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:23Z","timestamp":1792787603007,"version":"4.5.0"},"reference-count":85,"publisher":"American Society for Clinical Investigation","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Delaney AIDS Research Enterprise","award":["1UM1AI126611-01,1UM1AI164560-01"],"award-info":[{"award-number":["1UM1AI126611-01,1UM1AI164560-01"]}],"id":[{"id":"https:\/\/ror.org\/040gxv777","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Health and Medical Research Council","award":["APP1149990)"],"award-info":[{"award-number":["APP1149990)"]}],"id":[{"id":"https:\/\/ror.org\/011kf5r70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Agence Nationale de Recherches sur le Sida et les Hepatites Virales","award":["ANRS2018-02,ECTZ 118551\/118554,ECTZ 205320\/305352,ECTZ103104,ECTZ101971"],"award-info":[{"award-number":["ANRS2018-02,ECTZ 118551\/118554,ECTZ 205320\/305352,ECTZ103104,ECTZ101971"]}],"id":[{"id":"https:\/\/ror.org\/01kv58h76","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Sidaction","award":["13457"],"award-info":[{"award-number":["13457"]}],"id":[{"id":"https:\/\/ror.org\/04z6q9z55","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Argentinean National Agency of Promotion of Science and Technology","award":["PICT 2019-2019-01044,PICT 2020-00501"],"award-info":[{"award-number":["PICT 2019-2019-01044,PICT 2020-00501"]}]},{"name":"amfAR, The Foundation for AIDS Research","award":["110561-75-RKRL"],"award-info":[{"award-number":["110561-75-RKRL"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:p>\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ), the causative agent of tuberculosis (TB), is the most common coinfection in people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However, the immunological and virological mechanisms driving this progression are not completely understood. To address this knowledge gap, using pleural effusion samples from people living with HIV-1 and TB, we investigated how the HIV-1 genetic landscape and the anti\u2013HIV-1 immune response are impacted by a TB-associated microenvironment. Our results revealed an enrichment of genetically intact HIV-1 and impaired CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2013mediated antiviral response at this site of HIV-1\/\n                    <jats:italic>Mtb<\/jats:italic>\n                    coinfection. Moreover, efficient CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation was inhibited by lipids present in the TB-associated pleural effusion. These findings indicate that this immune microenvironment induced by TB promotes the persistence of cells infected with replication-competent HIV-1 by creating a niche of reduced antiviral immune pressure, potentially contributing to the worsened clinical outcomes observed in people living with HIV-1 and TB.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.201268","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:01:00Z","timestamp":1787241660000},"source":"Crossref","is-referenced-by-count":0,"title":["The pleural tuberculosis\u2013associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell\u2013mediated viral control"],"prefix":"10.1172","volume":"11","author":[{"given":"Samantha","family":"Cronin","sequence":"first","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Simpson","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pereyra-Casanova","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Li","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Mar\u00edn-Rojas","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freja A.","family":"Warner van Dijk","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Fisher","sequence":"additional","affiliation":[{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Buffa","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa","family":"Rana","sequence":"additional","affiliation":[{"name":"The University of Sydney, Faculty of Medicine and Health, Sydney, New South Wales, Australia."},{"name":"The Westmead Institute for Medical Rese arch, Centre for Virus Research, Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00ef","family":"Vahlas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse, CNRS, Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquina","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Medicina, Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Buenos Aires, Argentina."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 Universidad de Buenos Aires. 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