{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:22:20Z","timestamp":1787509340682,"version":"build-2736575974"},"reference-count":83,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005295","name":"American Academy of Pediatrics","doi-asserted-by":"crossref","award":["Marshall Klaus Award"],"award-info":[{"award-number":["Marshall Klaus Award"]}],"id":[{"id":"10.13039\/100005295","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"crossref","award":["Early Career Research Award"],"award-info":[{"award-number":["Early Career Research Award"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI155577,AI115712,AI117950,AI108545,AI082630,AI149680,HL145754"],"award-info":[{"award-number":["AI155577,AI115712,AI117950,AI108545,AI082630,AI149680,HL145754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:p>\n                    Although inflammatory complications are common in preterm infants, the effects of these conditions on neonatal immune development remain poorly defined. We therefore investigated whether severe bronchopulmonary dysplasia (BPD) and systemic infection, 2 major complications of prematurity, produce distinct immune signatures and change immune composition over time. We performed longitudinal high-dimensional immune profiling of residual whole blood from 38 preterm infants sampled every 2 weeks, along with 10 term infants at birth. Preterm infants with severe BPD showed a progressive increase in Th17-polarized CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, neutrophils, and Th17-related cytokines compared with age-matched infants with moderate BPD. In contrast, some preterm infants with systemic bacterial or viral infections mounted exceptionally robust CD8\n                    <jats:sup>+<\/jats:sup>\n                    , CD4\n                    <jats:sup>+<\/jats:sup>\n                    , and \u03b3\u03b4 T cell responses, with oligoclonal expansion, terminal differentiation, and coordinated plasma cytokine shifts that persisted well beyond resolution of infection. These findings demonstrate that different preterm comorbidities imprint the neonatal immune system in divergent ways. Thus, comprehensive and longitudinal immune profiling may not only identify connections between clinical inflammatory complications and underlying immune pathways but also reveal potential targets for intervention.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.201342","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:44:36Z","timestamp":1776890676000},"source":"Crossref","is-referenced-by-count":1,"title":["Perturbation of the preterm human immune system in early life"],"prefix":"10.1172","volume":"11","author":[{"given":"Benjamin A.","family":"Fensterheim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."},{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"McKeague","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-7358","authenticated-orcid":true,"given":"Divij","family":"Mathew","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Shwetank","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajinkya","family":"Pattekar","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahabia","family":"Rangwala","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Nasta","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macy C.","family":"Kee","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Clendenin","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Oncology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Diorio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Oncology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison R.","family":"Greenplate","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Immune Health and"},{"name":"Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Lingappan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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