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Here, we establish a model of experimental autoimmune adrenalitis that recapitulates key features of AD and reveals sex-dependent differences in disease manifestation within the model. Immunization with peptides derived from the adrenal self-antigen CYP11A1 induces corticosterone insufficiency. We show that autoimmune adrenalitis is driven by IFN-\u03b3 produced by self-reactive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, promoting granulomatous inflammation in the adrenal cortex. 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