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However, the primary drivers of metabolic alterations involved in this process remain incompletely understood. Here, we employed multiomics profiling of clinical samples to investigate metabolic alterations during wound healing. Our analyses revealed significant activation of the TCA cycle and identified \u03b1-ketoglutarate (\u03b1KG) as a central regulator orchestrating the reparative phase. Systemic administration of \u03b1KG promoted wound closure and re-epithelialization, characterized by enhanced neo-tissue formation with an extended epithelial tongue. Mechanistically, \u03b1KG promoted cell proliferation via the cell cycle pathway and enhanced fibroblast-derived TGF-\u03b2 signaling to induce epithelial-mesenchymal transition\u2013like programs in epithelial cells. To address the spatial metabolic heterogeneity, we developed a transdermal MN platform based on gelatin methacryloyl for localized \u03b1KG delivery, further accelerating tissue repair. 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