{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:43:38Z","timestamp":1793108618534,"version":"4.5.0"},"reference-count":81,"publisher":"American Society for Clinical Investigation","issue":"11","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Veterans Administration","award":["I01CX001777"],"award-info":[{"award-number":["I01CX001777"]}]},{"name":"FDA","award":["75F40122C00134"],"award-info":[{"award-number":["75F40122C00134"]}]},{"name":"CoViPa - Virological and immunological determinants of COVID-19 pathogenesis","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI135964,P01AG049665,P01HL154998,P01HL169188,U19AI181102,R01HL153312,R01ES034350,U54AG079754,R01HL147575,R01HL147290,R21AG075423,R01HL158139,R01HL149883,R01HL153122,R01AI158530,U01TR003528,R01HL149883-01"],"award-info":[{"award-number":["U19AI135964,P01AG049665,P01HL154998,P01HL169188,U19AI181102,R01HL153312,R01ES034350,U54AG079754,R01HL147575,R01HL147290,R21AG075423,R01HL158139,R01HL149883,R01HL153122,R01AI158530,U01TR003528,R01HL149883-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:p>\n                    Community-acquired pneumonia is a major cause of morbidity and mortality globally. Specific molecular endotypes are currently not well defined, and different viral or bacterial pathogens may trigger specific host responses and pathogenic mechanisms. We performed longitudinal proteomic profiling of bronchoalveolar lavage fluid and plasma from bacterial, influenza, and SARS-CoV-2\u2013driven pneumonia. Our analysis revealed highly pneumonia type\u2013specific proteomic signatures, including COVID-19\u2013specific antibodies locally produced in the lung. These antibodies showed biased immunoglobulin V\u2013domain usage, linked to a\n                    <jats:italic>CD69<\/jats:italic>\n                    \/\n                    <jats:italic>CD83<\/jats:italic>\n                    plasma cell state associated with disease severity and degree of autoimmunity. Using mass spectrometry\u2013driven autoantibody profiling in 2 independent COVID-19 cohorts, we identified 177 putative autoantibodies targeting extracellular matrix, nuclear, and immune-related proteins. Of note, temporal changes in autoantibody profiles correlated with clinical markers of inflammation, organ dysfunction, and duration of hospitalization. These findings highlight the autoimmune aspects of COVID-19 and provide potential biomarkers and therapeutic targets to help improve patient outcomes.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.203056","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:54:14Z","timestamp":1780937654000},"source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal clinical proteomics reveals pneumonia type\u2013specific protein biomarkers and autoantibodies"],"prefix":"10.1172","volume":"11","author":[{"given":"Anna","family":"Semenova","sequence":"first","affiliation":[{"name":"Research Unit for Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor A.","family":"Poor","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, 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