{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:09:17Z","timestamp":1788804557058,"version":"build-2803163510"},"reference-count":64,"publisher":"American Society for Clinical Investigation","issue":"17","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["P01HL172729"],"award-info":[{"award-number":["P01HL172729"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"crossref","award":["1456724"],"award-info":[{"award-number":["1456724"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000124","name":"Office of Research on Women\u2019s Health","doi-asserted-by":"crossref","award":["8K12AR084232-24"],"award-info":[{"award-number":["8K12AR084232-24"]}],"id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL158906"],"award-info":[{"award-number":["HL158906"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:p>\n                    Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure. While T cells are elevated in IPF lungs, their contributions to fibrosis beyond inflammation remain poorly understood. Here, we performed multiplex imaging and single-cell RNA and protein profiling on about 90,000 CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells from control and fibrotic lungs, revealing 11 distinct subsets of CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, including a rare CD56\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cell. In addition to increased T cell numbers in severely fibrotic lungs compared with non-diseased controls, we observed CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells localized near epithelial cells and in niches of abnormal epithelium. CXCR4\/MIF signaling emerged as a central axis mediating T cell\u2013epithelial interactions, while epidermal growth factor receptor (EGFR) and TGF-\u03b2 pathways dominated in multiple T cell subsets. Our findings support the concept that T cells in IPF adopt nonclassical activation patterns that are driven by epithelial interactions within the fibrotic microenvironment. These studies provide a foundation for exploring alternative therapeutic strategies in IPF lungs by modulating T cell behavior and communication networks.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.203080","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:01:06Z","timestamp":1788804066000},"source":"Crossref","is-referenced-by-count":0,"title":["Multiomic analysis identifies T cell subsets and mechanisms of epithelial interaction in idiopathic pulmonary fibrosis"],"prefix":"10.1172","volume":"11","author":[{"given":"Ana P.M.","family":"Serezani","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.R.","family":"Bazzano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno D.","family":"Pascoalino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmilla","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail J.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Sherrill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Vannan","sequence":"additional","affiliation":[{"name":"Translational Genomics Research Institute, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla L.","family":"Calvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula I.","family":"Gonzalez-Ericsson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Oncology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Wilfong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."},{"name":"Department of Medicine, Division of Rheumatology and Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-4484","authenticated-orcid":true,"given":"Matthew","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-0288","authenticated-orcid":true,"given":"Ciara M.","family":"Shaver","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-4702","authenticated-orcid":true,"given":"Lorraine B.","family":"Ware","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-2309","authenticated-orcid":true,"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-3247","authenticated-orcid":true,"given":"Nicholas E.","family":"Banovich","sequence":"additional","affiliation":[{"name":"Translational Genomics Research Institute, Phoenix, Arizona, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Kropski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA."},{"name":"Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA."},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA."},{"name":"Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24011-0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01384-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead273"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0027-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181365"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102243"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.94"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016245"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.020"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.67"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0418OC"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26045-w"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190557"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81591-z"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0959OC"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00163814"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17358-3"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0542-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00574.2020"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200601-001TK"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.6.L1192"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1972"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01888-z"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2024.05.010"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02080-x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55845-w"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1018"},{"key":"B29","doi-asserted-by":"crossref","unstructured":"Corbo S, et al. The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression [preprint]. https:\/\/doi.org\/10.1101\/2024.08.13.607778 Posted on bioRxiv August 13, 2024","DOI":"10.1101\/2024.08.13.607778"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02391-6"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01469-w"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31369-2"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2024.100758"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2509156123"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/path.6073"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2007.05.013"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.084"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.013"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23042-x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-024-00466-6"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102237"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35519-4"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210105"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219214"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.717892"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.023"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/srep14757"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108418"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01589-9"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2022.2160558"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.07.058"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05338-5"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.05.004"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1080\/01902148.2016.1199744"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19124105"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00288.2020"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1044"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad6872"},{"issue":"2","key":"B59","first-page":"91","article-title":"Signaling mechanisms coupled to CXCL12\/CXCR4-mediated cellular proliferation are PTEN-dependent","volume":"3","author":"Begley","year":"2015","journal-title":"Am J Clin Exp Urol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24964"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-56"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200694"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl5197"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/203080\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:01:53Z","timestamp":1788804113000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/203080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":64,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,7,23]]},"published-print":{"date-parts":[[2026,9,8]]}},"alternative-id":["10.1172\/jci.insight.203080"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.203080","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"article-number":"e203080"}}